From Psychosis to Recovery: A Case Report of N-Methyl-D-Aspartate (NMDA) Receptor Encephalitis

被引：0

作者：

Gopal, Sava Nanda ^{[1
]}

Vakati, Deepthi ^{[1
]}

Palanisamy, Saranya ^{[1
]}

David, Kanimozhi ^{[1
]}

Rajendran, Kannan ^{[1
]}

机构：

[1] Saveetha Univ, Saveetha Med Coll & Hosp, Saveetha Inst Med & Tech Sci, Internal Med, Chennai, India

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2024年 / 16卷 / 08期

关键词：

immunotherapy; antibodies; encephalitis; nmda receptor; autoimmune; DIAGNOSIS;

D O I：

10.7759/cureus.67272

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Autoimmune N-methyl-D-aspartate (NMDA) receptor encephalitis is an increasingly recognized cause of severe neuropsychiatric illness, particularly in young individuals. This case report presents a detailed account of a patient diagnosed with NMDA receptor encephalitis, highlighting the clinical presentation, diagnostic challenges, and treatment approach. The patient exhibited initial symptoms of psychosis and memory disturbances, which rapidly progressed to seizures and autonomic instability, reflecting the characteristic progression of the disorder.

引用

页数：9

共 12 条

[1] Herpes simplex virus encephalitis is a trigger of brain autoimmunity [J].

Armangue, Thais ;

Leypoldt, Frank ;

Malaga, Ignacio ;

Raspall-Chaure, Miquel ;

Marti, Itxaso ;

Nichter, Charles ;

Pugh, John ;

Vicente-Rasoamalala, Monica ;

Lafuente-Hidalgo, Miguel ;

Macaya, Alfons ;

Ke, Michael ;

Titulaer, Maarten J. ;

Hoeftberger, Romana ;

Sheriff, Heather ;

Glaser, Carol ;

Dalmau, Josep .

ANNALS OF NEUROLOGY, 2014, 75 (02) :317-323

[2] Anti-N-methyl-D-aspartate receptor encephalitis: review of clinical presentation, diagnosis and treatment [J].

Barry, Helen ;

Byrne, Susan ;

Barrett, Elizabeth ;

Murphy, Kieran C. ;

Cotter, David R. .

BJPSYCH BULLETIN, 2015, 39 (01) :19-23

[3] A case report: anti-NMDA receptor encephalitis [J].

Bhat, Pavan ;

Ahmed, Ameer ;

Jolepalem, Preetam ;

Sittambalam, Charmian .

JOURNAL OF COMMUNITY HOSPITAL INTERNAL MEDICINE PERSPECTIVES, 2018, 8 (03) :158-160

[4] Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma [J].

Dalmau, Josep ;

Tuzun, Erdem ;

Wu, Hai-yan ;

Masjuan, Jaime ;

Rossi, Jeffrey E. ;

Voloschin, Alfredo ;

Baehring, Joachim M. ;

Shimazaki, Haruo ;

Koide, Rej ;

King, Dale ;

Mason, Warren ;

Sansing, Lauren H. ;

Dichter, Marc A. ;

Rosenfeld, Myrna R. ;

Lynch, David R. .

ANNALS OF NEUROLOGY, 2007, 61 (01) :25-36

[5] Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis [J].

Dalmau, Josep ;

Lancaster, Eric ;

Martinez-Hernandez, Eugenia ;

Rosenfeld, Myrna R. ;

Balice-Gordon, Rita .

LANCET NEUROLOGY, 2011, 10 (01) :63-74

[6] Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies [J].

Dalmau, Josep ;

Gleichman, Amy J. ;

Hughes, Ethen G. ;

Rossi, Jeffrey E. ;

Peng, Xiaoyu ;

Lai, Meizan ;

Dessain, Scott K. ;

Rosenfeld, Mynna R. ;

Balice-Gordon, Rita ;

Lynch, David R. .

LANCET NEUROLOGY, 2008, 7 (12) :1091-1098

[7] A clinical approach to diagnosis of autoimmune encephalitis [J].

Graus, Francesc ;

Titulaer, Maarten J. ;

Balu, Ramani ;

Benseler, Susanne ;

Bien, Christian G. ;

Cellucci, Tania ;

Cortese, Irene ;

Dale, Russell C. ;

Gelfand, Jeffrey M. ;

Geschwind, Michael ;

Glaser, Carol A. ;

Honnorat, Jerome ;

Hoeftberger, Romana ;

Iizuka, Takahiro ;

Irani, Sarosh R. ;

Lancaster, Eric ;

Leypoldt, Frank ;

Pruess, Harald ;

Rae-Grant, Alexander ;

Reindl, Markus ;

Rosenfeld, Myrna R. ;

Rostasy, Kevin ;

Saiz, Albert ;

Venkatesan, Arun ;

Vincent, Angela ;

Wandinger, Klaus-Peter ;

Waters, Patrick ;

Dalmau, Josep .

LANCET NEUROLOGY, 2016, 15 (04) :391-404

[8] Therapeutic potential of N-methyl-D-aspartate receptor modulators in psychiatry [J].

Hanson, Jesse E. ;

Yuan, Hongjie ;

Perszyk, Riley E. ;

Banke, Tue G. ;

Xing, Hao ;

Tsai, Ming-Chi ;

Menniti, Frank S. ;

Traynelis, Stephen F. .

NEUROPSYCHOPHARMACOLOGY, 2024, 49 (01) :51-66

[9] Anti-N-methyl-D-aspartate receptor encephalitis: A review of pathogenic mechanisms, treatment, prognosis [J].

Huang, Qianyi ;

Xie, Yue ;

Hu, Zhiping ;

Tang, Xiangqi .

BRAIN RESEARCH, 2020, 1727

[10] Anti-NMDA Receptor Autoimmune Encephalitis Diagnosis and Management Strategies [J].

Nguyen, Linda ;

Wang, Cynthia .

INTERNATIONAL JOURNAL OF GENERAL MEDICINE, 2023, 16 :7-21

← 1 2 →