Preparation of magnetic scaffolds via supercritical carbon dioxide foaming process using iron oxide nanoparticles coated with CO2-philic materials as nucleating agents

被引：0

作者：

Jiao, Zhen ^{[1
,2
,3
]}

Zhang, Shuo ^{[1
,2
]}

Wang, Jinjing ^{[2
,3
]}

Zhang, Yi ^{[2
,3
]}

机构：

[1] Southeast Univ, Sch Chem & Chem Engn, Nanjing 211189, Jiangsu, Peoples R China

[2] Jiangsu Key Lab Biomat & Devices, Nanjing, Jiangsu, Peoples R China

[3] Joint Res Inst Southeast Univ & Monash Univ, Suzhou, Jiangsu, Peoples R China

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2024年 / 141卷 / 47期

基金：

中国国家自然科学基金;

关键词：

CO2-philic materials; iron oxide nanoparticles; magnetic scaffolds; multi-modal porous structures; supercritical carbon dioxide foaming process; TISSUE; DESIGN; CO2;

D O I：

10.1002/app.56256

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The iron oxide nanoparticles (IONs), coated with different materials, are synthesized and utilized as nucleating agents to prepare magnetic multi-modal porous scaffolds of poly (lactic-co-glycolic acid)/IONs using the supercritical carbon dioxide (ScCO2) foaming process. The effects of the modification materials, including citric acid, polycaprolactone, and polyvinyl acetate, on the foaming process and properties of the magnetic scaffolds are systematically investigated. The results indicate that the solubility and diffusion ability of CO2 in the foaming materials played a vital role in the foaming process. The use of CO2-philic materials and high pressure proves beneficial in generating micropores. The scaffolds with multi-modal porous structures can be obtained at relatively low pressure for the ScCO2 foaming systems evaluated in this study. Furthermore, the prepared scaffolds exhibit high porosity and a good compressive modulus (higher than 0.4 MPa), satisfying the requirements of tissue engineering for soft tissue scaffolds.

引用

页数：15