RNA Modifications Shape Hematopoietic Stem Cell Aging: Beyond the Code

被引：1
作者：
van Der Werf, Inge [1 ]
Sneifer, Jenna [1 ]
Jamieson, Catriona [1 ]
机构：
[1] Univ Calif San Diego, Sanford Stem Cell Inst, Moores Canc Ctr, Div Regenerat Med,Dept Med, La Jolla, CA 92037 USA
来源：
FEBS LETTERS | 2024年 / 598卷 / 22期
关键词：
ADAR1; Aging; APOBEC3; Hematopoiesis; RNA Editing; RNA Splicing; Stem Cells; SELF-RENEWAL; ADAR1; MAINTENANCE; REVERSAL; EVENTS;
D O I：
10.1002/1873-3468.15014
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hematopoietic system aging is characterized by both hematopoietic stem cell (HSC) and niche degeneration resulting in myeloid lineage-biased differentiation, reduced B cell and T cell lymphopoiesis, increased HSC mobilization, and fat deposition in the bone marrow.image Both alterations in RNA splicing and editing during HSC aging contribute to increased myeloid lineage skewing and inflammation-responsive transcription factors, underscoring the importance of epitranscriptomic mechanisms in the acquisition of an age-related phenotype.
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收藏
页码：2774 / 2775
页数：2
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