Health economic evaluation of an artificial intelligence (AI)-based rapid nutritional diagnostic system for hospitalised patients: A multicentre, randomised controlled trial

被引:0
|
作者
Sun, Ming-Yao [1 ,2 ]
Wang, Yu [1 ]
Zheng, Tian [2 ]
Wang, Xue [1 ]
Lin, Fan [2 ]
Zheng, Lu-Yan [2 ]
Wang, Mao-Yue [1 ]
Zhang, Pian-Hong [3 ]
Chen, Lu-Ying [3 ]
Yao, Ying [4 ]
Sun, Jie [4 ]
Li, Zeng-Ning [5 ,6 ,7 ]
Hu, Huan-Yu [5 ,6 ,8 ]
Jiang, Hua [8 ]
Yue, Han-Yang [8 ]
Zhao, Qian [9 ]
Wang, Hai-Yan [9 ]
Han, Lei [10 ]
Ma, Xuan [10 ]
Ji, Meng-Ting [10 ]
Xu, Hong-Xia [11 ]
Luo, Si-Yu [11 ]
Liu, Ying-Hua [12 ]
Zhang, Yong [12 ]
Han, Ting [13 ]
Li, Yan-Sheng [14 ]
Hou, Peng-Peng [14 ]
Chen, Wei [1 ]
机构
[1] Chinese Acad Med Sci Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Clin Nutr, 1 Shuaifuyuan, Beijing 100730, Peoples R China
[2] Fujian Med Univ, Fuzhou Univ Affiliated Prov Hosp, Fujian Prov Hosp, Shengli Clin Med Coll,Dept Clin Nutr,Fujian Key La, Fuzhou, Peoples R China
[3] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Clin Nutr, Hangzhou, Peoples R China
[4] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Nutr, Wuhan, Peoples R China
[5] Hebei Med Univ, Hosp 1, Dept Clin Nutr, Shijiazhuang, Peoples R China
[6] Hebei Key Lab Nutr & Hlth, Shijiazhuang, Peoples R China
[7] Hebei Med Univ, Hosp Stomatol, Shijiazhuang, Peoples R China
[8] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Inst Emergency & Disaster Med, Sichuan Acad Med Sci,Sch Med, Chengdu, Peoples R China
[9] Ningxia Hui Autonomous Reg Peoples Hosp, Dept Clin Nutr, Yinchuan, Peoples R China
[10] Qingdao Univ, Affiliated Hosp, Dept Clin Nutr, Qingdao, Chin, Myanmar
[11] Third Mil Med Univ, Daping Hosp, Dept Clin Nutr, Chongqing, Peoples R China
[12] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Nutr, Beijing, Peoples R China
[13] Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Clin Nutr, Shanghai, Peoples R China
[14] DHC Mediway Technol Co Ltd, Beijing, Peoples R China
基金
中国国家自然科学基金;
关键词
Artificial intelligence; Nutritional assessment; Incremental cost-effectiveness ratio; Randomised controlled trial; SUBJECTIVE GLOBAL ASSESSMENT; CLINICAL NUTRITION; MALNUTRITION;
D O I
10.1016/j.clnu.2024.08.030
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background & aims: Malnutrition is prevalent among hospitalised patients, and increases the morbidity, mortality, and medical costs; yet nutritional assessments on admission are not routine. This study assessed the clinical and economic benefits of using an artificial intelligence (AI)-based rapid nutritional diagnostic system for routine nutritional screening of hospitalised patients. Methods: A nationwide multicentre randomised controlled trial was conducted at 11 centres in 10 provinces. Hospitalised patients were randomised to either receive an assessment using an AI-based rapid nutritional diagnostic system as part of routine care (experimental group), or not (control group). The overall medical resource costs were calculated for each participant and a decision-tree was generated based on an intention-to-treat analysis to analyse the cost-effectiveness of various treatment modalities. Subgroup analyses were performed according to clinical characteristics and a probabilistic sensitivity analysis was performed to evaluate the influence of parameter variations on the incremental cost-effectiveness ratio (ICER). Results: In total, 5763 patients participated in the study, 2830 in the experimental arm and 2933 in the control arm. The experimental arm had a significantly higher cure rate than the control arm (23.24% versus 20.18%; p 1/4 0.005). The experimental arm incurred an incremental cost of 276.52 CNY, leading to an additional 3.06 cures, yielding an ICER of 90.37 CNY. Sensitivity analysis revealed that the decisiontree model was relatively stable. Conclusion: The integration of the AI-based rapid nutritional diagnostic system into routine inpatient care substantially enhanced the cure rate among hospitalised patients and was cost-effective. Registration: NCT04776070 (https://clinicaltrials.gov/study/NCT04776070). (c) 2024 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
引用
收藏
页码:2327 / 2335
页数:9
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