Fabrication of Mupirocin-Loaded PEGylated Chitosan Nanoparticulate Films for Enhanced Wound Healing

被引：3

作者：

Azeez, Shajahan ^{[1
,2
]}

Sathiyaseelan, Anbazhagan ^{[3
]}

Venkatesan, Kaviyarasan ^{[1
]}

Wang, Myeong-Hyeon ^{[3
]}

机构：

[1] Univ Madras, Ctr Adv Studies Bot, Guindy Campus, Chennai 600025, India

[2] Vinayaka Missions Res Fdn DU, Aarupadai Veedu Med Coll & Hosp, Dept Med Biotechnol, Pondicherry 607402, India

[3] Kangwon Natl Univ, Dept Biohlth Convergence, Chunchon 24341, South Korea

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 17期

基金：

新加坡国家研究基金会;

关键词：

chitosan; mupirocin; PEG; composite film; in vivo; wound healing; CARTILAGE; DELIVERY; RELEASE; CHITIN; AREA;

D O I：

10.3390/ijms25179188

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chitosan-based biomaterials are being investigated for their unique properties that support skin regeneration and wound healing. This study focused on the preparation and characterization of a mupirocin (Mup)-loaded PEGylated chitosan (CS-PEG) nanoparticulate film (NF) [CBNF]. The CBNF was characterized using FTIR spectroscopy and SEM analysis. The results demonstrated that CBNF was successfully incorporated into the composites, as shown by functional group modification through FTIR analysis. Additionally, the SEM micrograph revealed the deposition of nanoparticles (<200 nm) on the surface of transparent CBNF. The film has higher water absorption (>= 1700%) and moderate water retention ability within 6 h. Furthermore, histological findings showed significant development, with re-epithelialization and granulation of tissues after 19 days, indicating the healing efficiency of CNBF. These results suggest that drug-loaded films could be an effective carrier and delivery agent for Mup-like anti-inflammatory drugs.

引用

页数：18

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