The effect of Nigella sativa supplementation on glycemic status in adults: An updated systematic review and meta-analysis of randomized controlled trials

被引:0
作者
Shirvani, Shabnam [1 ]
Falahatzadeh, Maryam [2 ]
Oveili, Elham [3 ]
Jamali, Mehrdad [4 ]
Pam, Pedram [4 ]
Parang, Maryam [5 ]
Shakarami, Mehrnaz [6 ]
机构
[1] Islamic Azad Univ, Tehran Med Sci, Tehran, Iran
[2] Shiraz Univ Med Sci, Dept Pharm, Shiraz, Iran
[3] Azad Islamic Univ Med Sci, Dept Pharmaceut Sci, Tehran, Iran
[4] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran
[5] Bushehr Univ Med Sci, Fac Hlth & Nutr, Dept Nutr, Bushehr, Iran
[6] Isfahan Univ Med Sci, Esfahan, Iran
关键词
Nigella sativa; Glycemic control; Type; 2; diabetes; Systematic review; Meta-analysis; DOUBLE-BLIND; SATIVA OIL; PLACEBO; BIOMARKERS; EXTRACT; WOMEN;
D O I
10.1016/j.prostaglandins.2024.106885
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This systematic review and meta-analysis of randomized controlled trials (RCTs) sought to evaluate the effects of Nigella sativa (N. sativa) consumption on glycemic index in adults. A systematic literature search up to December 2023 was completed in PubMed, Scopus, and Web of Science, to identify eligible RCTs. Random effects models were assessed based on the heterogeneity tests, and pooled data were determined as weighted mean differences with a 95 % confidence interval. Finally, a total of 30 studies were found to be eligible for this meta-analysis. The pooled results using random effects model indicated that N. sativa supplementation significantly reduced FBS (SMD: -1.71; 95 % CI: -2.11, -1.31, p <0.001; I-2= 92.7 %, p-heterogeneity <0.001) and HA1c levels (SMD: -2.16; 95 % CI: -3.04, -1.29, p <0.001; I-2= 95.7 %, p-heterogeneity <0.001) but not effect on insulin (SMD = 0.48; 95 % CI: -0.53, 1.48, P = 0.353; I-2= 96.1 %, p-heterogeneity <0.001), and HOMA-IR (SMD: -0.56; 95 % CI: -1.47, 0.35, p=0.229; I-2= 95.0 %, p-heterogeneity <0.001).Overall, the evidence supports the consumption of N. sativa to reduce FBS and HA1c levels. Additional research, featuring extended durations and robust study designs, is necessary to determine the ideal dosage and duration of N. sativa supplementation for achieving a positive impact on glycemic markers.
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页数:11
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