Atramacrolodes A-D (1-4), Four Undescribed Eudesmane-Type Sesquiterpenes from the Rhizome of Atractylodes macrocephala

被引：1

作者：

Li, Bei ^{[1
]}

Tian, Yulu ^{[1
]}

Guo, Xinyi ^{[1
]}

Ren, Yating ^{[1
]}

Ma, Jie ^{[1
]}

Zang, Yingda ^{[1
]}

Sun, Hua ^{[1
]}

Zhang, Dongming ^{[1
]}

Li, Chuangjun ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2024年 / 21卷 / 08期

基金：

国家重点研发计划;

关键词：

Atramacrolodes A-D; eudesmane-type sesquiterpenes; biological activities; Atractylodes macrocephala;

D O I：

10.1002/cbdv.202400817

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four undescribed sesquiterpenes, atramacrolodes A-D (1-4), along with six known compounds 5-10 were isolated from the rhizome of Atractylodes macrocephala. Compound 3 possessed a new skeleton based on an unprecedented carton-carton connection. Their structures were determined by UV, IR, HRESIMS, NMR spectra, C-13 NMR calculation with DP4(+) analysis, and the comparison of experimental and calculated ECD spectra. Compounds 5 and 8 showed protective effects against paracetamol-induced liver cell injury.

引用

页数：7

共 9 条

[1] Eudesmane-type sesquiterpenes from the rhizomes of Atractylodes macrocephala and their bioactivities
Zhang, Hai-Xin
Si, Jin-Guang
Li, Jing-Rong
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Zhao, Chen-Xu
Zhang, Tao
Zou, Zhong-Mei
PHYTOCHEMISTRY, 2023, 206
[2] New eudesmane-type sesquiterpenoids from the processed rhizomes of Atractylodes macrocephala
Li, Ying
Yang, Xiu-Wei
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2014, 16 (02) : 123 - 128
[3] Axiriabilines A-D, uncommon nitrogenous eudesmane-type sesquiterpenes from the Hainan sponge Axinyssa variabilis
Li, Xu-Wen
Chen, Si-Han
Ye, Fei
Mollo, Ernesto
Zhu, Wei-Liang
Liu, Hai-Li
Guo, Yue-Wei
TETRAHEDRON, 2017, 73 (34) : 5239 - 5243
[4] Four new eudesmane-type sesquiterpenes from the basal leaves of Salvia plebeia R. Br.
Dai, Yiqun
Liu, Li
Xie, Guoyong
Chen, Yujie
Qin, Xiaoying
Wang, Qi
Li, Jie
Qin, Minjian
FITOTERAPIA, 2014, 94 : 142 - 147
[5] Chlorahupetenes A-D, Four Eudesmane-Type Sesquiterpenoid Dimer Enantiomers with Two Unusual Carbon Skeletons from Chloranthus henryi Var. hupehensis
Zhang, Dan-Yang
Zhou, Jing-Jing
Yang, Hui
Wang, Min
Wang, Ya-Nan
Liu, Shuai
Zhang, Zi-Mo
Zhuang, Peng-Yu
Wang, Xiao-Xia
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JOURNAL OF ORGANIC CHEMISTRY, 2022, 87 (13): : 8623 - 8632
[6] Four new eudesmane-type and one new eremophilane-type sesquiterpenes from the whole plant of Carpesium abrotanoides L.
Fan, Yu-Wen
Zhang, Wei-Jie
Ao, Zhuo-Yi
Chen, Jia-Yan
Lian, Xin
Pan, Yong-Chen
Chen, Li-Ping
Jiang, Dong-Xu
Wu, Jie-Wei
FITOTERAPIA, 2023, 169
[7] Strobilols A-D:: Four cadinane-type sesquiterpenes from the edible mushroom Strobilurus ohshimae
Hiramatsu, Fuminori
Murayama, Tetsuya
Koseki, Takuya
Shiono, Yoshihito
PHYTOCHEMISTRY, 2007, 68 (09) : 1267 - 1271
[8] (+)/(−)-Phaeocaulin A-D, four pairs of new enantiomeric germacrane-type sesquiterpenes from Curcuma phaeocaulis as natural nitric oxide inhibitors
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De-juan Sun
Jiang-hao Ma
Yue Liu
Feng Zhao
Paul Owusu Donkor
Li-qin Ding
Li-xia Chen
Feng Qiu
Scientific Reports, 7
[9] (+)/(-)- Phaeocaulin A-D, four pairs of new enantiomeric germacrane-type sesquiterpenes from Curcuma phaeocaulis as natural nitric oxide inhibitors
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Sun, De-juan
Ma, Jiang-hao
Liu, Yue
Zhao, Feng
Donkor, Paul Owusu
Ding, Li-qin
Chen, Li-xia
Qiu, Feng
SCIENTIFIC REPORTS, 2017, 7

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