Acetazolamide as an Add-on Therapy Following Barbed Reposition Pharyngoplasty in Obstructive Sleep Apnea: A Randomized Controlled Trial

被引:2
|
作者
Hellemans, Simon [1 ,2 ]
Van de Perck, Eli [1 ,2 ]
Van Loo, Dorine [2 ]
Verbraecken, Johan [1 ,3 ,4 ]
Sands, Scott A. [5 ,6 ]
Azarbarzin, Ali [5 ,6 ]
Dieltjens, Marijke [1 ,2 ,7 ]
Op De Beeck, Sara [1 ]
Vroegop, Anneclaire [1 ,2 ]
Vanderveken, Olivier M. [1 ,2 ,3 ,7 ]
机构
[1] Univ Antwerp, Fac Med & Hlth Sci, B-2610 Antwerp, Antwerp, Belgium
[2] Antwerp Univ Hosp, ENT Head & Neck Surg, B-2650 Edegem, Belgium
[3] Antwerp Univ Hosp, Multidisciplinary Sleep Disorders Ctr, B-2650 Edegem, Belgium
[4] Antwerp Univ Hosp, Dept Pulmonol, B-2650 Edegem, Belgium
[5] Brigham & Womens Hosp, Div Sleep & Circadian Disorders, Boston, MA 02115 USA
[6] Harvard Med Sch, Boston, MA 02115 USA
[7] Antwerp Univ Hosp, Special Dent Care, B-2650 Edegem, Belgium
来源
LIFE-BASEL | 2024年 / 14卷 / 08期
关键词
acetazolamide; loop gain; OSA; pharmacotherapy; pharyngoplasty; upper airway surgery; UPPER AIRWAY; LOOP GAIN; EFFICACY; ADHERENCE; HYPOXIA;
D O I
10.3390/life14080963
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Surgical interventions, like barbed reposition pharyngoplasty (BRP), are a valuable alternative for patients with obstructive sleep apnea (OSA) who are unable to tolerate continuous positive airway pressure (CPAP). However, predicting surgical success remains challenging, partly due to the contribution of non-anatomical factors. Therefore, combined medical treatment with acetazolamide, known to stabilize respiratory drive, may lead to superior surgical results. This double-blind, parallel-group randomized controlled trial evaluates the efficacy of acetazolamide as an add-on therapy to BRP in OSA. A total of 26 patients with moderate to severe OSA undergoing BRP were randomized to receive either acetazolamide or placebo post-surgery for 16 weeks. The group who was treated with BRP in combination with acetazolamide showed a reduction in AHI of 69.4%, significantly surpassing the 32.7% reduction of the BRP + placebo group (p < 0.01). The sleep apnea-specific hypoxic burden also decreased significantly in the group who was treated with BRP + acetazolamide (p < 0.01), but not in the group receiving BRP + placebo (p = 0.28). Based on these results, acetazolamide as an add-on therapy following BRP surgery shows promise in improving outcomes for OSA patients, addressing both anatomical and non-anatomical factors.
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页数:12
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