Cutting edge of immune response and immunosuppressants in allogeneic and xenogeneic islet transplantation

被引:0
|
作者
Yue, Liting [1 ]
Li, Jisong [2 ]
Yao, Mingjun [1 ]
Song, Siyuan [3 ]
Zhang, Xiaoqin [1 ]
Wang, Yi [1 ,4 ]
机构
[1] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Ctr Crit Care Med, Chengdu, Sichuan, Peoples R China
[2] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Gastrointestinal Surg, Chengdu, Peoples R China
[3] Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA
[4] Sichuan Prov Peoples Hosp, Clin Immunol Translat Med Key Lab Sichuan Prov, Chengdu, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
基金
中国国家自然科学基金;
关键词
islet transplantation; immune response; immunosuppressants; xenotransplantation; allogenic and xenogenic islet transplantation; MEDIATED INFLAMMATORY REACTION; PANCREATIC BETA-CELLS; VERSUS-HOST-DISEASE; ALTERNATIVE COMPLEMENT PATHWAY; LONG-TERM FUNCTION; TISSUE FACTOR; DIABETES-MELLITUS; XENOGRAFT REJECTION; T-CELLS; MYCOPHENOLATE-MOFETIL;
D O I
10.3389/fimmu.2024.1455691
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
As an effective treatment for diabetes, islet transplantation has garnered significant attention and research in recent years. However, immune rejection and the toxicity of immunosuppressive drugs remain critical factors influencing the success of islet transplantation. While immunosuppressants are essential in reducing immune rejection reactions and can significantly improve the survival rate of islet transplants, improper use of these drugs can markedly increase mortality rates following transplantation. Additionally, the current availability of islet organ donations fails to meet the demand for organ transplants, making xenotransplantation a crucial method for addressing organ shortages. This review will cover the following three aspects: 1) the immune responses occurring during allogeneic islet transplantation, including three stages: inflammation and IBMIR, allogeneic immune response, and autoimmune recurrence; 2) commonly used immunosuppressants in allogeneic islet transplantation, including calcineurin inhibitors (Cyclosporine A, Tacrolimus), mycophenolate mofetil, glucocorticoids, and Bortezomib; and 3) early and late immune responses in xenogeneic islet transplantation and the immune effects of triple therapy (ECDI-fixed donor spleen cells (ECDI-SP) + anti-CD20 + Sirolimus) on xenotransplantation.
引用
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页数:20
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