The role of radiotherapy in the treatment of sinonasal undifferentiated carcinoma: A population-based analysis

被引：0
作者：
Zhao, Xin [1 ]
Pei, Ziqi [1 ]
Song, Xiang [1 ]
Jin, Gang [1 ]
机构：
[1] Shanxi Med Univ, Hosp 2, Dept Oncol, Taiyuan, Shanxi, Peoples R China
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2025年 / 47卷 / 01期
关键词：
chemotherapy; prognosis; radiotherapy; sinonasal undifferentiated carcinoma; surgery; MANAGEMENT; PATTERNS; THERAPY; MALIGNANCIES; EXPERIENCE; SURVIVAL; MODALITY; OUTCOMES; FAILURE;
D O I：
10.1002/hed.27862
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
BackgroundSinonasal undifferentiated carcinoma (SNUC) is a rare, aggressive disease with ambiguous management and poor prognosis. This study aimed to evaluate the role of radiation therapy (RT) and explore the optimal treatment sequence.MethodsRetrospective analysis of survival trends of 410 SNUC patients between 1973 and 2015.ResultsThe 5-year cancer-specific survival (CSS) rate (45.1%) and overall survival (OS) rates (38.1%) were reported in the 84-month median follow-up. Radiotherapy was a prognosticator for improving CSS (hazard ratio [HR] = 0.425, 95% confidence interval [CI]: 0.299-0.603, p = 0.000) and OS (HR = 0.415, 95% CI: 0.303-0.570, p = 0.000), either with surgery (p = 0.000) or without surgery (p = 0.000). However, in a combined therapy of surgery and RT, preoperative and postoperative RT (5-year OS rates were 47.1% and 45.6%, respectively, p = 0.486) were not significantly different.ConclusionsRadiotherapy plays a key role in improving SNUC survival rates. No significant difference in survival rates was observed in preoperative and postoperative RT treatment.
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收藏
页码：150 / 158
页数：9
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