Legionella maceachernii pneumonia: a case report and literature review

被引：0

作者：

Pan, Gaofeng ^{[1
,2
,3
]}

Fu, Maoying ^{[1
]}

Ni, Huihui ^{[1
]}

Zhang, Wei ^{[1
]}

Yao, Yi ^{[1
]}

Xie, Yingcong ^{[1
]}

Li, Jing ^{[1
]}

Zhang, Yijia ^{[1
]}

Wang, Yuting ^{[1
]}

Han, Kexing ^{[2
,3
]}

Gao, Yufeng ^{[2
,3
]}

机构：

[1] First Peoples Hosp Kunshan, Dept Infect Dis, Kunshan, Jiangsu, Peoples R China

[2] Anhui Med Univ, Affiliated Hosp 1, Dept Infect Dis, 218 Jixi Rd, Hefei 230022, Anhui, Peoples R China

[3] Anhui Med Univ, Anhui Prov Key Lab Infect Dis, Hefei, Anhui, Peoples R China

来源：

POSTGRADUATE MEDICINE | 2024年 / 136卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Legionella maceachernii; pneumonia; metagenomic testing; quinolone antibiotics; rare disease; PATIENT;

D O I：

10.1080/00325481.2024.2385888

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Legionella maceachernii pneumonia is a severe respiratory infection with low incidence but high mortality. However, the optimal treatment for this disease remains unclear. We report a case of successful treatment of Legionella maceachernii pneumonia, which is the first report of such a case in China. Case presentation: An 87-year-old man with concomitant chronic obstructive pulmonary disease, liver cirrhosis, and history of left nephrectomy was diagnosed with Legionella maceachernii pneumonia using Dano-seq pathogen metagenomic testing. After two weeks of treatment with cefoperazone/sulbactam combined with quinolone antibiotics, the patient showed improvement and was discharged. The patient continued to take oral quinolone antibiotics for one week after discharge and recovered during outpatient follow-up. Conclusions: Dano-seq pathogen metagenomic testing can rapidly diagnose Legionella maceachernii pneumonia, and taking quinolone antibiotics is an effective treatment.

引用

页码：678 / 682

页数：5

共 15 条

[1] Clinical and Laboratory Diagnosis of Legionella Pneumonia [J].

Bai, Lu ;

Yang, Wei ;

Li, Yuanyuan .

DIAGNOSTICS, 2023, 13 (02)

[2] Legionella maceachernii soft tissue infection [J].

Chee, Cheng E. ;

Baddour, Larry M. .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2007, 334 (05) :410-413

[3] Application of Nanopore Sequencing in the Diagnosis and Treatment of Pulmonary Infections [J].

Chen, Jie ;

Xu, Feng .

MOLECULAR DIAGNOSIS & THERAPY, 2023, 27 (06) :685-701

[4] Legionnaires' disease [J].

Cunha, Burke A. ;

Burillo, Almudena ;

Bouza, Emilio .

LANCET, 2016, 387 (10016) :376-385

[5] Legionella maceachernii pneumonia in a patient with HIV infection [J].

Dumoff, K ;

McGovern, PC ;

Edelstein, PH ;

Nachamkin, I .

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2004, 50 (02) :141-145

[6]

Jarraud Sophie, 2013, Methods Mol Biol, V954, P27, DOI 10.1007/978-1-62703-161-5_2

[7] Metagenomic sequencing at the epicenter of the Nigeria 2018 Lassa fever outbreak [J].

Kafetzopoulou, L. E. ;

Pullan, S. T. ;

Lemey, P. ;

Suchard, M. A. ;

Ehichioya, D. U. ;

Pahlmann, M. ;

Thielebein, A. ;

Hinzmann, J. ;

Oestereich, L. ;

Wozniak, D. M. ;

Efthymiadis, K. ;

Schachten, D. ;

Koenig, F. ;

Matjeschk, J. ;

Lorenzen, S. ;

Lumley, S. ;

Ighodalo, Y. ;

Adomeh, D. I. ;

Olokor, T. ;

Omomoh, E. ;

Omiunu, R. ;

Agbukor, J. ;

Ebo, B. ;

Aiyepada, J. ;

Ebhodaghe, P. ;

Osiemi, B. ;

Ehikhametalor, S. ;

Akhilomen, P. ;

Airende, M. ;

Esumeh, R. ;

Muoebonam, E. ;

Giwa, R. ;

Ekanem, A. ;

Igenegbale, G. ;

Odigie, G. ;

Okonofua, G. ;

Enigbe, R. ;

Oyakhilome, J. ;

Yerumoh, E. O. ;

Odia, I. ;

Aire, C. ;

Okonofua, M. ;

Atafo, R. ;

Tobin, E. ;

Asogun, D. ;

Akpede, N. ;

Okokhere, P. O. ;

Rafiu, M. O. ;

Iraoyah, K. O. ;

Iruolagbe, C. O. .

SCIENCE, 2019, 363 (6422) :74-+

[8] ISOLATION OF LEGIONELLA-MACEACHERNII FROM AN IMMUNOCOMPROMISED PATIENT WITH SEVERE UNDERLYING LUNG-DISEASE [J].

MERRELL, WH ;

MORITZ, A ;

BUTT, HL ;

BARNETT, G ;

EATHER, GW ;

BISHOP, JM .

MEDICAL JOURNAL OF AUSTRALIA, 1991, 155 (06) :415-417

[9] Severe community acquired pneumonia due to Legionella maceachernii infection [J].

Pasparaki, Eirini ;

Chochlakis, Dimosthenis ;

Damianaki, Angeliki ;

Psaroulaki, Anna .

ARCHIVOS DE BRONCONEUMOLOGIA, 2015, 51 (02) :97-98

[10] Oxford nanopore sequencing in clinical microbiology and infection diagnostics [J].

Sheka, Dropen ;

Alabi, Nikolay ;

Gordon, Paul M. K. .

BRIEFINGS IN BIOINFORMATICS, 2021, 22 (05)

← 1 2 →