From pathophysiology to practice: addressing oxidative stress and sperm DNA fragmentation in Varicocele-affected subfertile men

被引：0
|
作者：
Neto, Filipe Tenorio Lira [1 ,2 ,3 ]
Campos, Lucas Ribeiro [4 ]
Roque, Matheus [5 ]
Esteves, Sandro C. [6 ,7 ,8 ]
机构：
[1] Andros Recife, Recife, PE, Brazil
[2] Inst Med Integral Prof Fernando Figueira, Dept Urol, Recife, PE, Brazil
[3] Hosp Santa Joana Recife, Recife, PE, Brazil
[4] Univ Fed Minas Gerais UFMG, Dept Urol, Belo Horizonte, MG, Brazil
[5] Mater Prime, Dept Med Reprod, Sao Paulo, SP, Brazil
[6] ANDROFERT Clin Androl & Reprod Humana, Ctr Referencia Reprod Masculina, Campinas, SP, Brazil
[7] Univ Estadual Campinas UNICAMP, Dept Cirurgia, Disciplina Urol, Campinas, SP, Brazil
[8] Aarhus Univ, Fac Hlth, Dept Clin Med, Aarhus, Denmark
来源：
INTERNATIONAL BRAZ J UROL | 2024年 / 50卷 / 05期
关键词：
Infertility; Male; Oxidative Stress; Varicocele; Reproductive Techniques; Assisted; DEOXYRIBONUCLEIC-ACID DAMAGE; IMPAIRED SEMEN QUALITY; INFERTILE PATIENTS; SUBCLINICAL VARICOCELE; MICROSURGICAL VARICOCELECTOMY; CHROMATIN CONDENSATION; EJACULATED SPERMATOZOA; UNTREATED VARICOCELE; ANTIOXIDANT CAPACITY; DIAGNOSTIC-ACCURACY;
D O I：
10.1590/S1677-5538.IBJU.2024.9917
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Varicocele can reduce male fertility potential through various oxidative stress mechanisms. Excessive production of reactive oxygen species may overwhelm the sperm's defenses against oxidative stress, damaging the sperm chromatin. Sperm DNA fragmentation, in the form of DNA strand breaks, is recognized as a consequence of the oxidative stress cascade and is commonly found in the ejaculates of men with varicocele and fertility issues. This paper reviews the current knowledge regarding the association between varicocele, oxidative stress, sperm DNA fragmentation, and male infertility, and examines the role of varicocele repair in alleviating oxidative-sperm DNA fragmentation in these patients. Additionally, we highlight areas for further research to address knowledge gaps relevant to clinical practice.
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页数：159
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