Photoredox cross-dehydrogenative C(sp2)-C(sp3) coupling of heteroarenes with secondary amines through 1,5-HAT

被引：1
|
作者：
Srinivasu, Vinjamuri [1 ]
Pattanaik, Swadhin [2 ]
Sureshkumar, Devarajulu [1 ]
机构：
[1] Indian Inst Sci Educ & Res Kolkata, Dept Chem Sci, Mohanpur 741246, West Bengal, India
[2] Indian Inst Sci Educ & Res, Dept Chem Sci, Berhampur 760010, Odisha, India
来源：
CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 72期
关键词：
METAL; TRANSITION; QUINOXALIN-2(1H)-ONES; DERIVATIVES; ALKYLATION;
D O I：
10.1039/d4cc02818j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The functionalization of alpha-C(sp(3))-H bonds in amines has become a focal point of contemporary research. Here, we report a new approach utilizing photocatalysis alpha-C(sp(3))-H bond functionalization in alicyclic and aliphatic secondary amines facilitated by intramolecular 1,5-hydrogen atom transfer (HAT). This finding unlocks a sustainable method for rapidly constructing complex heterocyclics via cross-dehydrogenative C-C coupling of protected amines and nitrogen-containing heterocycles. This protocol boasts broad applicability to various substrates, exhibits tolerance to numerous functional groups, and supports the late-stage modification of drug molecules.
引用
收藏
页码：9757 / 9760
页数：4
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