In Vitro Anti-HIV-1 Activity of Fucoidans from Brown Algae

被引：0

作者：

Nosik, Marina N. ^{[1
]}

Krylova, Natalya V. ^{[2
]}

Usoltseva, Roza V. ^{[3
]}

Surits, Valerii V. ^{[3
]}

Kireev, Dmitry E. ^{[4
]}

Shchelkanov, Mikhail Yu. ^{[2
]}

Svitich, Oxana A. ^{[1
]}

Ermakova, Svetlana P. ^{[3
]}

机构：

[1] II Mechnikov Inst Vaccines & Sera, Moscow 105064, Russia

[2] GP Somov Inst Epidemiol & Microbiol, Vladivostok 690087, Russia

[3] Russian Acad Sci, GB Elyakov Pacific Inst Bioorgan Chem, Far Eastern Branch, Vladivostok 690022, Russia

[4] Cent Res Inst Epidemiol, Moscow 111123, Russia

来源：

MARINE DRUGS | 2024年 / 22卷 / 08期

关键词：

brown algae; fucoidans; HIV-1; anti-HIV-1; activity; HIV; POLYSACCHARIDES; ANTICANCER; ENTRY; ASSAY;

D O I：

10.3390/md22080355

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Due to the developing resistance and intolerance to antiretroviral drugs, there is an urgent demand for alternative agents that can suppress the viral load in people living with human immunodeficiency virus (HIV). Recently, there has been increased interest in agents of marine origin such as, in particular, fucoidans to suppress HIV replication. In the present study, the anti-HIV-1 activity of fucoidans from the brown algae Alaria marginata, Alaria ochotensis, Laminaria longipes, Saccharina cichorioides, Saccharina gurianovae, and Tauya basicrassa was studied in vitro. The studied compounds were found to be able to inhibit HIV-1 replication at different stages of the virus life cycle. Herewith, all fucoidans exhibited significant antiviral activity by affecting the early stages of the virus-cell interaction. The fucoidan from Saccharina cichorioides showed the highest virus-inhibitory activity by blocking the virus' attachment to and entry into the host's cell, with a selectivity index (SI) > 160.

引用

页数：13

共 59 条

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