Is PCSK9 the Key Player in the Ischemia-Reperfusion Match?

被引：1
作者：
Benedetti, Alice [1 ]
Del Monte, Alvise [2 ]
机构：
[1] Jessaziekenhuis, Hartcentrum, Hasselt, Belgium
[2] Vrije Univ Brussel, Univ Ziekenhuis Brussel, Heart Rhythm Management Ctr, Brussels, Belgium
来源：
CIRCULATION-CARDIOVASCULAR IMAGING | 2024年 / 17卷 / 08期
关键词：
Editorial; cholesterol; LDL; magnetic resonance imaging; PCSK9; ST elevation myocardial infarction; ACUTE CORONARY SYNDROME; REDUCING LIPIDS; EFFICACY; INJURY; SAFETY; CMR;
D O I：
10.1161/CIRCIMAGING.124.017210
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页数：3
相关论文
共 18 条
[1]   Plasma PCSK9 Levels Are Elevated with Acute Myocardial Infarction in Two Independent Retrospective Angiographic Studies [J].
Almontashiri, Naif A. M. ;
Vilmundarson, Ragnar O. ;
Ghasemzadeh, Nima ;
Dandona, Sonny ;
Roberts, Robert ;
Quyyumi, Arshed A. ;
Chen, Hsiao-Huei ;
Stewart, Alexandre F. R. .
PLOS ONE, 2014, 9 (09)
[2]   PCSK9 expression in the ischaemic heart and its relationship to infarct size, cardiac function, and development of autophagy [J].
Ding, Zufeng ;
Wang, Xianwei ;
Liu, Shijie ;
Shahanawaz, Jiwani ;
Theus, Sue ;
Fan, Yubo ;
Deng, Xiaoyan ;
Zhou, Sichang ;
Mehta, Jawahar L. .
CARDIOVASCULAR RESEARCH, 2018, 114 (13) :1738-1751
[3]   Pharmacological rationale for the very early treatment of acute coronary syndrome with monoclonal antibodies anti-PCSK9 [J].
Ferri, Nicola ;
Ruscica, Massimiliano ;
Lupo, Maria Giovanna ;
Vicenzi, Marco ;
Sirtori, Cesare R. ;
Corsini, Alberto .
PHARMACOLOGICAL RESEARCH, 2022, 184
[4]   Physiological and therapeutic regulation of PCSK9 activity in cardiovascular disease [J].
Glerup, Simon ;
Schulz, Rainer ;
Laufs, Ulrich ;
Schlueter, Klaus-Dieter .
BASIC RESEARCH IN CARDIOLOGY, 2017, 112 (03)
[5]   Effect of Microvascular Obstruction and Intramyocardial Hemorrhage by CMR on LV Remodeling and Outcomes After Myocardial Infarction A Systematic Review and Meta-Analysis [J].
Hamirani, Yasmin S. ;
Wong, Andrew ;
Kramer, Christopher M. ;
Salerno, Michael .
JACC-CARDIOVASCULAR IMAGING, 2014, 7 (09) :940-952
[6]   Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice [J].
Lagace, Thomas A. ;
Curtis, David E. ;
Garuti, Rita ;
McNutt, Markey C. ;
Park, Sahng Wook ;
Prather, Heidi B. ;
Anderson, Norma N. ;
Ho, Y. K. ;
Hammer, Robert E. ;
Horton, Jay D. .
JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (11) :2995-3005
[7]   Circulating Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Predicts Future Risk of Cardiovascular Events Independently of Established Risk Factors [J].
Leander, Karin ;
Malarstig, Anders ;
van't Hooft, Ferdinand M. ;
Hyde, Craig ;
Hellenius, Mai-Lis ;
Troutt, Jason S. ;
Konrad, Robert J. ;
Ohrvik, John ;
Hamsten, Anders ;
de Faire, Ulf .
CIRCULATION, 2016, 133 (13) :1230-1239
[8]   Evolution of Myocardial Tissue Injury A CMR Study Over a Decade After STEMI [J].
Mayr, Agnes ;
Klug, Gert ;
Reindl, Martin ;
Lechner, Ivan ;
Tiller, Christina ;
Holzknecht, Magdalena ;
Pamminger, Mathias ;
Troger, Felix ;
Schocke, Michael ;
Bauer, Axel ;
Reinstadler, Sebastian J. ;
Metzler, Bernhard .
JACC-CARDIOVASCULAR IMAGING, 2022, 15 (06) :1030-1042
[9]   Effects of routine early treatment with PCSK9 inhibitors in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: a randomised, double-blind, sham-controlled trial [J].
Mehta, Shamir R. ;
Pare, Guillaume ;
Lonn, Eva M. ;
Jolly, Sanjit S. ;
Natarajan, Madhu K. ;
Pinilla-Echeverri, Natalia ;
Schwalm, Jon-David ;
Sheth, Tej N. ;
Sibbald, Matthew ;
Tsang, Michael ;
Valettas, Nicholas ;
Velianou, James L. ;
Lee, Shun Fu ;
Ferdous, Tahsin ;
Nauman, Sadia ;
Nguyen, Helen ;
McCready, Tara ;
McQueen, Matthew J. .
EUROINTERVENTION, 2022, 18 (11) :888-+
[10]   Proprotein Convertase Subtilisin/Kexin Type 9 Monoclonal Antibodies for Acute Coronary Syndrome A Narrative Review [J].
Navarese, Eliano P. ;
Kolodziejczak, Michalina ;
Kereiakes, Dean J. ;
Tantry, Udaya S. ;
O'Connor, Christopher ;
Gurbel, Paul A. .
ANNALS OF INTERNAL MEDICINE, 2016, 164 (09) :600-+
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