Cross-talks between perivascular adipose tissue and neighbors: multifaceted nature of nereids

被引：4

作者：

Li, Yujuan ^{[1
,2
,3
]}

Chen, Zhang ^{[1
,2
,3
]}

Xiao, Ying ^{[4
]}

Li, Xinzhi ^{[1
,2
,3
]}

机构：

[1] Macau Univ Sci & Technol, Fac Med, Sch Pharm, Macau, Peoples R China

[2] Macau Univ Sci & Technol, R&D Ctr Lab Drug Discovery Nat Resource, Macau, Peoples R China

[3] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Macau, Peoples R China

[4] Macau Univ Sci & Technol, Fac Med, Macau, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2024年 / 15卷

关键词：

perivascular adipose tissue; secretome; intercellular communication; obesity; cardiovascular disease; NADPH OXIDASE ACTIVITY; T-CELL; NEOINTIMAL HYPERPLASIA; ENDOTHELIAL FUNCTION; ANEURYSM FORMATION; INFLAMMATION; FAT; EXPRESSION; OBESITY; ATHEROSCLEROSIS;

D O I：

10.3389/fphar.2024.1442086

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Perivascular adipose tissue (PVAT) is a unique fat depot surrounding blood vessels and plays a vital role in the progression of vascular remodeling and dysfunction. PVAT exhibits remarkable differences in structure, phenotype, origin, and secretome across anatomical locations. The proximity of PVAT to neighboring vascular beds favors a niche for bidirectional communication between adipocytes and vascular smooth muscle cells, endothelial cells, and immune cells. In this review, we update our understanding of PVAT's regional differences and provide a comprehensive exploration of how these differences impact cross-talks between PVAT and the vascular wall. Different PVAT depots show different degrees of vasoprotective function and resilience to pathological changes such as obesity and vasculopathies, shaping multifaceted interactions between PVAT depots and adjacent vasculatures. The depot-specific resilience may lead to innovative strategies to manage cardiometabolic disorders.

引用

页数：12

共 106 条

[1] Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling [J].

Adachi, Yusuke ;

Ueda, Kazutaka ;

Nomura, Seitaro ;

Ito, Kaoru ;

Katoh, Manami ;

Katagiri, Mikako ;

Yamada, Shintaro ;

Hashimoto, Masaki ;

Zhai, Bowen ;

Numata, Genri ;

Otani, Akira ;

Hinata, Munetoshi ;

Hiraike, Yuta ;

Waki, Hironori ;

Takeda, Norifumi ;

Morita, Hiroyuki ;

Ushiku, Tetsuo ;

Yamauchi, Toshimasa ;

Takimoto, Eiki ;

Komuro, Issei .

NATURE COMMUNICATIONS, 2022, 13 (01)

[2] Sex differences in the regulation of porcine coronary artery tone by perivascular adipose tissue: a role of adiponectin? [J].

Ahmad, Abdulla A. ;

Randall, Michael D. ;

Roberts, Richard E. .

BRITISH JOURNAL OF PHARMACOLOGY, 2017, 174 (16) :2773-2783

[3] Defining the lineage of thermogenic perivascular adipose tissue [J].

Angueira, Anthony R. ;

Sakers, Alexander P. ;

Holman, Corey D. ;

Cheng, Lan ;

Arbocco, Michelangella N. ;

Shamsi, Farnaz ;

Lynes, Matthew D. ;

Shrestha, Rojesh ;

Okada, Chihiro ;

Batmanov, Kirill ;

Susztak, Katalin ;

Tseng, Yu-Hua ;

Liaw, Lucy ;

Seale, Patrick .

NATURE METABOLISM, 2021, 3 (04) :469-+

[4] Detecting human coronary inflammation by imaging perivascular fat [J].

Antonopoulos, Alexios S. ;

Sanna, Fabio ;

Sabharwal, Nikant ;

Thomas, Sheena ;

Oikonomou, Evangelos K. ;

Herdman, Laura ;

Margaritis, Marios ;

Shirodaria, Cheerag ;

Kampoli, Anna-Maria ;

Akoumianakis, Ioannis ;

Petrou, Mario ;

Sayeed, Rana ;

Krasopoulos, George ;

Psarros, Constantinos ;

Ciccone, Patricia ;

Brophy, Carl M. ;

Digby, Janet ;

Kelion, Andrew ;

Uberoi, Raman ;

Anthony, Suzan ;

Alexopoulos, Nikolaos ;

Tousoulis, Dimitris ;

Achenbach, Stephan ;

Neubauer, Stefan ;

Channon, Keith M. ;

Antoniades, Charalambos .

SCIENCE TRANSLATIONAL MEDICINE, 2017, 9 (398)

[5] Aging Exacerbates Obesity-Induced Oxidative Stress and Inflammation in Perivascular Adipose Tissue in Mice: A Paracrine Mechanism Contributing to Vascular Redox Dysregulation and Inflammation [J].

Bailey-Downs, Lora C. ;

Tucsek, Zsuzsanna ;

Toth, Peter ;

Sosnowska, Danuta ;

Gautam, Tripti ;

Sonntag, William E. ;

Csiszar, Anna ;

Ungvari, Zoltan .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2013, 68 (07) :780-792

[6] Protective Role of Perivascular Adipose Tissue in Endothelial Dysfunction and Insulin-Induced Vasodilatation of Hypercholesterolemic LDL Receptor-Deficient Mice [J].

Baltieri, Natali ;

Guizoni, Daniele M. ;

Victorio, Jamaira A. ;

Davel, Ana P. .

FRONTIERS IN PHYSIOLOGY, 2018, 9

[7] Characterization of the adipocyte cellular lineage in vivo [J].

Berry, Ryan ;

Rodeheffer, Matthew S. .

NATURE CELL BIOLOGY, 2013, 15 (03) :302-308

[8] Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice [J].

Bruemmer, D ;

Collins, AR ;

Noh, G ;

Wang, W ;

Territo, M ;

Arias-Magallona, S ;

Fishbein, MC ;

Blaschke, F ;

Kintscher, U ;

Graf, K ;

Law, RE ;

Hsueh, WA .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 112 (09) :1318-1331

[9] β3-Adrenoceptor stimulation of perivascular adipocytes leads to increased fat cell-derived NO and vascular relaxation in small arteries [J].

Bussey, Charlotte E. ;

Withers, Sarah B. ;

Saxton, Sophie N. ;

Bodagh, Neil ;

Aldous, Robert G. ;

Heagerty, Anthony M. .

BRITISH JOURNAL OF PHARMACOLOGY, 2018, 175 (18) :3685-3698

[10] Perivascular Adipose Tissue Modulation of Neurogenic Vasorelaxation of Rat Mesenteric Arteries [J].

Chang, Hsi-Hsien ;

Yang, Stephen Shei-Dei ;

Chang, Shang-Jen .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2020, 75 (01) :21-30

← 1 2 3 4 5 6 7 8 9 10 →