Risk Factors for Sinusoidal Obstruction Syndrome After Hematopoietic Stem Cell Transplantation in Children and Young Adults: A Systematic Review and Meta-Analysis

被引：0
作者：
Cui, Kai [1 ]
Chen, Jie [1 ]
Zhang, Senlin [1 ]
He, ChenChen [1 ]
Sun, Shan [1 ]
Li, Jie [1 ]
机构：
[1] Soochow Univ, Dept Hematol & Oncol, Childrens Hosp, Suzhou, Peoples R China
来源：
CLINICAL TRANSPLANTATION | 2024年 / 38卷 / 09期
关键词：
children; hematopoietic stem cell transplantation; meta-analysis; risk factors; sinusoidal obstruction syndrome; young adults; HEPATIC VENOOCCLUSIVE DISEASE; MARROW TRANSPLANTATION; PROSPECTIVE COHORT; BONE-MARROW; BLOOD; BUSULFAN;
D O I：
10.1111/ctr.15449
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Objective and Background: Sinusoidal obstruction syndrome (SOS) is a life-threatening complication in hematopoietic stem cell transplantation (HSCT) patients. However, the related risk factors in pediatric and young adult HSCT recipients remain unclear. Thus, we conducted this meta-analysis to identify potential risk factors for SOS in children and young adults undergoing HSCT. Method: We acquired related articles through searching PubMed, EMBASE, and the Cochrane Library up to May 31, 2024. We calculated odds ratios (ORs) and corresponding 95% confidence intervals (CIs) to identify potential risk factors. Results: A total of 12 studies with 7644 HSCT recipients were included. Bone marrow transplantation (OR = 1.35, 95% CI: 1.03-1.77, I-2 = 0%), busulfan (BU) (OR = 3.63, 95% CI: 1.78-7.38, I-2 = 70%), and fludarabine (FLU) (OR = 1.55, 95% CI: 1.09-2.21, I-2 = 16%) were risk factors for SOS after HSCT in children and young adults. Conclusion: Bone marrow transplantation and the use of BU or FLU might be risk factors for SOS after HSCT in children and young adults.
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页数：9
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