Risk Factors for Sinusoidal Obstruction Syndrome After Hematopoietic Stem Cell Transplantation in Children and Young Adults: A Systematic Review and Meta-Analysis

被引：0

作者：

Cui, Kai ^{[1
]}

Chen, Jie ^{[1
]}

Zhang, Senlin ^{[1
]}

He, Chenchen ^{[1
]}

Sun, Shan ^{[1
]}

Li, Jie ^{[1
]}

机构：

[1] Soochow Univ, Childrens Hosp, Dept Hematol & Oncol, Suzhou, Peoples R China

来源：

CLINICAL TRANSPLANTATION | 2024年 / 38卷 / 09期

关键词：

children; hematopoietic stem cell transplantation; meta-analysis; risk factors; sinusoidal obstruction syndrome; young adults;

D O I：

10.1111/ctr.15449

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Objective and Background: Sinusoidal obstruction syndrome (SOS) is a life-threatening complication in hematopoietic stem cell transplantation (HSCT) patients. However, the related risk factors in pediatric and young adult HSCT recipients remain unclear. Thus, we conducted this meta-analysis to identify potential risk factors for SOS in children and young adults undergoing HSCT. Method: We acquired related articles through searching PubMed, EMBASE, and the Cochrane Library up to May 31, 2024. We calculated odds ratios (ORs) and corresponding 95% confidence intervals (CIs) to identify potential risk factors. Results: A total of 12 studies with 7644 HSCT recipients were included. Bone marrow transplantation (OR = 1.35, 95% CI: 1.03-1.77, I-2 = 0%), busulfan (BU) (OR = 3.63, 95% CI: 1.78-7.38, I-2 = 70%), and fludarabine (FLU) (OR = 1.55, 95% CI: 1.09-2.21, I-2 = 16%) were risk factors for SOS after HSCT in children and young adults. Conclusion: Bone marrow transplantation and the use of BU or FLU might be risk factors for SOS after HSCT in children and young adults.

引用

页数：9

共 42 条

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