Risk Factors for Sinusoidal Obstruction Syndrome After Hematopoietic Stem Cell Transplantation in Children and Young Adults: A Systematic Review and Meta-Analysis

被引：0
作者：
Cui, Kai [1 ]
Chen, Jie [1 ]
Zhang, Senlin [1 ]
He, Chenchen [1 ]
Sun, Shan [1 ]
Li, Jie [1 ]
机构：
[1] Soochow Univ, Childrens Hosp, Dept Hematol & Oncol, Suzhou, Peoples R China
来源：
CLINICAL TRANSPLANTATION | 2024年 / 38卷 / 09期
关键词：
children; hematopoietic stem cell transplantation; meta-analysis; risk factors; sinusoidal obstruction syndrome; young adults;
D O I：
10.1111/ctr.15449
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Objective and Background: Sinusoidal obstruction syndrome (SOS) is a life-threatening complication in hematopoietic stem cell transplantation (HSCT) patients. However, the related risk factors in pediatric and young adult HSCT recipients remain unclear. Thus, we conducted this meta-analysis to identify potential risk factors for SOS in children and young adults undergoing HSCT. Method: We acquired related articles through searching PubMed, EMBASE, and the Cochrane Library up to May 31, 2024. We calculated odds ratios (ORs) and corresponding 95% confidence intervals (CIs) to identify potential risk factors. Results: A total of 12 studies with 7644 HSCT recipients were included. Bone marrow transplantation (OR = 1.35, 95% CI: 1.03-1.77, I-2 = 0%), busulfan (BU) (OR = 3.63, 95% CI: 1.78-7.38, I-2 = 70%), and fludarabine (FLU) (OR = 1.55, 95% CI: 1.09-2.21, I-2 = 16%) were risk factors for SOS after HSCT in children and young adults. Conclusion: Bone marrow transplantation and the use of BU or FLU might be risk factors for SOS after HSCT in children and young adults.
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页数：9
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共 42 条
[1]   Incidence, survival and risk factors for the development of veno-occlusive disease in pediatric hematopoietic stem cell transplant recipients [J].
Barker, CC ;
Butzner, JD ;
Anderson, RA ;
Brant, R ;
Sauve, RS .
BONE MARROW TRANSPLANTATION, 2003, 32 (01) :79-87
[2]   Association Between the Magnitude of Intravenous Busulfan Exposure and Development of Hepatic Veno-Occlusive Disease in Children and Young Adults Undergoing Myeloablative Allogeneic Hematopoietic Cell Transplantation [J].
Bognar, Tim ;
Bartelink, Imke H. ;
Egberts, Toine C. G. ;
Rademaker, Carin M. A. ;
Versluys, A. Birgitta ;
Slatter, Mary A. ;
Kletzel, Morris ;
Nath, Christa E. ;
Cuvelier, Geoffrey D. E. ;
Savic, Rada M. ;
Dvorak, Christopher ;
Long-Boyle, Janel R. ;
Cowan, Morton J. ;
Bittencourt, Henrique ;
Bredius, Robbert G. M. ;
Gungor, Tayfun ;
Shaw, Peter J. ;
Ansari, Marc ;
Hassan, Moustapha ;
Krajinovic, Maja ;
Hempel, Georg ;
Marktel, Sarah ;
Chiesa, Robert ;
Theoret, Yves ;
Lund, Troy ;
Orchard, Paul J. ;
Wynn, Robert F. ;
Boelens, Jaap Jan ;
Lalmohamed, Arief .
TRANSPLANTATION AND CELLULAR THERAPY, 2022, 28 (04) :196-202
[3]   Diagnosis and Treatment of VOD/SOS After Allogeneic Hematopoietic Stem Cell Transplantation [J].
Bonifazi, Francesca ;
Barbato, Francesco ;
Ravaioli, Federico ;
Sessa, Mariarosaria ;
Defrancesco, Irene ;
Arpinati, Mario ;
Cavo, Michele ;
Colecchia, Antonio .
FRONTIERS IN IMMUNOLOGY, 2020, 11
[4]   Prospective cohort study comparing intravenous busulfan to total body irradiation in hematopoietic cell transplantation [J].
Bredeson, Christopher ;
LeRademacher, Jennifer ;
Kato, Kazunobu ;
DiPersio, John F. ;
Agura, Edward ;
Devine, Steven M. ;
Appelbaum, Frederick R. ;
Tomblyn, Marcie R. ;
Laport, Ginna G. ;
Zhu, Xiaochun ;
McCarthy, Philip L. ;
Ho, Vincent T. ;
Cooke, Kenneth R. ;
Armstrong, Elizabeth ;
Smith, Angela ;
Rizzo, J. Douglas ;
Burkart, Jeanne M. ;
Pasquini, Marcelo C. .
BLOOD, 2013, 122 (24) :3871-3878
[5]  
Carreras E, 1998, BLOOD, V92, P3599
[6]   The Incidence of Veno-Occlusive Disease Following Allogeneic Hematopoietic Stem Cell Transplantation Has Diminished and the Outcome Improved over the Last Decade [J].
Carreras, Enric ;
Diaz-Beya, Marina ;
Rosinol, Laura ;
Martinez, Carmen ;
Fernandez-Aviles, Francesc ;
Rovira, Montserrat .
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2011, 17 (11) :1713-1720
[7]  
Cesaro S, 2005, HAEMATOLOGICA, V90, P1396
[8]   Risk factors and mortality predictors of hepatic veno-occlusive disease after pediatric hematopoietic stem cell transplantation [J].
Cheuk, D. K. L. ;
Wang, P. ;
Lee, T. L. ;
Chiang, A. K. S. ;
Ha, S. Y. ;
Lau, Y. L. ;
Chan, G. C. F. .
BONE MARROW TRANSPLANTATION, 2007, 40 (10) :935-944
[9]   Interventions for prophylaxis of hepatic veno-occlusive disease in people undergoing haematopoietic stem cell transplantation [J].
Cheuk, Daniel K. L. ;
Chiang, Alan K. S. ;
Ha, Shau Yin ;
Chan, Godfrey C. F. .
COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2015, (05)
[10]   Diagnosing and Grading of Sinusoidal Obstructive Syndrome after Hematopoietic Stem Cell Transplant of Children, Adolescent and Young Adults treated in a Pediatric Institution with Pediatric Protocols [J].
Cisneros, Gabriel Salinas ;
Dvorak, Christopher C. ;
-Boyle, Janel Long ;
Kharbanda, Sandhya ;
Shimano, Kristin A. ;
Melton, Alexis ;
Chu, Julia ;
Winestone, Lena E. ;
Dara, Jasmeen ;
Huang, James N. ;
Hermiston, Michelle L. ;
Zinter, Matt ;
Higham, Christine S. .
TRANSPLANTATION AND CELLULAR THERAPY, 2024, 30 (07) :690.e1-690.e16
12345