BRAF V600E-mutated Colorectal Neuroendocrine Carcinoma Effectively Treated with a Chemotherapy Protocol for BRAF-mutated Metastatic Colorectal Cancer

被引：1

作者：

Owaki, Seira

Mori, Yoshinori ^{[1
]}

Nakai, Shunsuke

Maeda, Hideki

Imazu, Mitsuki

Tomita, Yusaku

Kanaiwa, Hiroki

Yamaguchi, Ayana

Kitagawa, Mika

Hirano, Atsuyuki

Kimura, Yoshihide

Tsuchida, Kenji

Kataoka, Hiromi

机构：

[1] Nagoya City Univ, West Med Ctr, Dept Gastroenterol, Nagoya, Japan

来源：

INTERNAL MEDICINE | 2024年 / 63卷 / 14期

关键词：

BRAF V600E-mutated colorectal neuroendocrine carcinoma; chemotherapy; MUTATIONS;

D O I：

10.2169/internalmedicine.2870-23

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Metastatic colorectal neuroendocrine carcinoma (NEC) is often treated using a chemotherapy protocol for small-cell lung cancer; however, the prognosis is extremely poor. A 55-year-old woman with BRAF V600Emutated transverse colon NEC and liver metastases underwent colectomy followed by FOLFOXIRI plus bevacizumab. Consequently, the liver metastases markedly shrank. Owing to later worsening of the liver metastases, she received encorafenib and binimetinib plus cetuximab. Despite discontinuing binimetinib due to myalgia, she had a long-term response with a progression-free survival of 14 months and an overall survival of more than 27 months. A chemotherapy protocol for BRAF-mutated metastatic colorectal cancer may be a treatment option for BRAF V600E-mutated colorectal NEC.

引用

页码：1995 / 1999

页数：5

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