Symptoms Associated With Exercise Intolerance and Resting Heart Rate Following Mild Traumatic Brain Injury

被引:0
作者
Thorne, Jacinta [1 ,3 ,5 ]
Hellewell, Sarah C. [3 ,5 ]
Cowen, Gill [2 ,3 ]
Ring, Alexander [1 ,6 ]
Jefferson, Amanda [2 ]
Chih, HuiJun [4 ]
Gozt, Aleksandra K. [3 ,5 ]
Buhagiar, Francesca [7 ]
Thomas, Elizabeth [4 ,8 ]
Papini, Melissa [3 ,5 ]
Bynevelt, Michael [10 ]
Celenza, Antonio [9 ,11 ]
Xu, Dan [2 ,4 ,12 ]
Honeybul, Stephen [13 ]
Pestell, Carmela F. [3 ,7 ]
Fatovich, Daniel [14 ,15 ]
Fitzgerald, Melinda [3 ,5 ]
机构
[1] Curtin Univ, Sch Allied Hlth, Bentley, WA, Australia
[2] Curtin Univ, Curtin Med Sch, Bentley, WA, Australia
[3] Curtin Hlth Innovat Res Inst, Fac Hlth Sci, Bentley, Australia
[4] Curtin Univ, Sch Populat Hlth, Bentley, WA, Australia
[5] Perron Inst Neurol & Translat Sci, Nedlands, WA, Australia
[6] Murdoch Univ, Inst Immunol & Infect Dis, Murdoch, WA, Australia
[7] Univ Western Australia, Sch Psychol Sci, Nedlands, WA, Australia
[8] Univ Western Australia, Div Surg, Nedlands, WA, Australia
[9] Univ Western Australia, Sch Med, Emergency Med, Nedlands, WA, Australia
[10] Sir Charles Gairdner Hosp, Neurol Intervent & Imaging Serv Western Australia, Nedlands, WA, Australia
[11] Sir Charles Gairdner Hosp, Emergency Dept, Nedlands, WA, Australia
[12] Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou, Peoples R China
[13] Royal Perth & Fiona Stanley Hosp, Sir Charles Gairdner, Perth, WA, Australia
[14] Univ Western Australia, Royal Perth Hosp, Emergency Med, Perth, Australia
[15] Harry Perkins Inst Med Res, Ctr Clin Res Emergency Med, Nedlands, WA, Australia
关键词
clinical profile; concussion; exercise; head injury; heart rate; mild traumatic brain injury; recovery; symptoms; CONCUSSION; DYSFUNCTION; SPORT; RECOMMENDATIONS; DISORDERS; SYSTEM; IMPACT;
D O I
10.1097/HTR.0000000000000928
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objectives:People may experience a myriad of symptoms after mild traumatic brain injury (mTBI), but the relationship between symptoms and objective assessments is poorly characterized. This study sought to investigate the association between symptoms, resting heart rate (HR), and exercise tolerance in individuals following mTBI, with a secondary aim to examine the relationship between symptom-based clinical profiles and recovery. Methods:Prospective observational study of adults aged 18 to 65 years who had sustained mTBI within the previous 7 days. Symptoms were assessed using the Post-Concussion Symptom Scale, HR was measured at rest, and exercise tolerance was assessed using the Buffalo Concussion Bike Test. Symptom burden and symptom-based clinical profiles were examined with respect to exercise tolerance and resting HR. Results:Data from 32 participants were assessed (mean age 36.5 +/- 12.6 years, 41% female, 5.7 +/- 1.1 days since injury). Symptom burden (number of symptoms and symptom severity) was significantly associated with exercise intolerance (P = .002 and P = .025, respectively). Physiological and vestibular-ocular clinical profile composite groups were associated with exercise tolerance (P = .001 and P = .014, respectively), with individuals who were exercise intolerant having a higher mean number of symptoms in each profile than those who were exercise tolerant. Mood-related and autonomic clinical profiles were associated with a higher resting HR (>80 bpm) (P = .048 and P = .028, respectively), suggesting altered autonomic response for participants with symptoms relating to this profile. After adjusting for age and mechanism of injury (sports- or non-sports-related), having a higher mood-related clinical profile was associated with persisting symptoms at 3 months postinjury (adjusted odds ratio = 2.08; 95% CI, 1.11-3.90; P = .013). Conclusion:Symptom-based clinical profiles, in conjunction with objective measures such as resting HR and exercise tolerance, are important components of clinical care for those having sustained mTBI. These results provide preliminary support for the concept that specific symptoms are indicative of autonomic dysfunction following mTBI.
引用
收藏
页码:E381 / E392
页数:12
相关论文
共 51 条
[1]   Therapeutic Effects of Meditation, Yoga, and Mindfulness-Based Interventions for Chronic Symptoms of Mild Traumatic Brain Injury: A Systematic Review and Meta-Analysis [J].
Acabchuk, Rebecca L. ;
Brisson, Julie M. ;
Park, Crystal L. ;
Babbott-Bryan, Noah ;
Parmelee, Olivia A. ;
Johnson, Blair T. .
APPLIED PSYCHOLOGY-HEALTH AND WELL BEING, 2021, 13 (01) :34-62
[2]   Defining asymptomatic status following sports concussion: fact or fallacy? [J].
Alla, Sridhar ;
Sullivan, S. John ;
McCrory, Paul .
BRITISH JOURNAL OF SPORTS MEDICINE, 2012, 46 (08) :562-569
[3]   Autonomic nervous system dysfunction in psychiatric disorders and the impact of psychotropic medications: a systematic review and meta-analysis [J].
Alvares, Gail A. ;
Quintana, Daniel S. ;
Hickie, Ian B. ;
Guastella, Adam J. .
JOURNAL OF PSYCHIATRY & NEUROSCIENCE, 2016, 41 (02) :89-104
[4]  
[Anonymous], 1993, J HEAD TRAUMA REHAB, V8, P86, DOI [DOI 10.1097/00001199-199309000-00010, 10.1097/00001199-199309000-00010]
[5]   Sensitivity to sounds in sport-related concussed athletes: a new clinical presentation of hyperacusis [J].
Assi, Hussein ;
Moore, R. Davis ;
Ellemberg, Dave ;
Hebert, Sylvie .
SCIENTIFIC REPORTS, 2018, 8
[6]   THE CENTRAL AUTONOMIC NETWORK - FUNCTIONAL-ORGANIZATION, DYSFUNCTION, AND PERSPECTIVE [J].
BENARROCH, EE .
MAYO CLINIC PROCEEDINGS, 1993, 68 (10) :988-1001
[7]   The impact of concussion on cardiac autonomic function: A systematic review [J].
Blake, Tracy A. ;
McKay, Carly D. ;
Meeuwisse, Willem H. ;
Emery, Carolyn A. .
BRAIN INJURY, 2016, 30 (02) :132-145
[8]   The effectiveness of oxytocin for treating substance use disorders:A systematic review of randomized placebo-controlled trials [J].
Mellentin, Angelina Isabella ;
Finn, Sara Wallhed ;
Skok, Lotte ;
Thaysen-Petersen, Daniel ;
Mistarz, Nicolaj ;
Fink-Jensen, Anders ;
Nielsen, Dorthe Gruner .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2023, 151
[9]   Methodological issues and research recommendations for mild traumatic brain injury: The WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury [J].
Carroll, LJ ;
Cassidy, JD ;
Holm, L ;
Kraus, J ;
Coronado, VG .
JOURNAL OF REHABILITATION MEDICINE, 2004, 36 :113-125
[10]   Research Imaging of Brain Structure and Function After Concussion [J].
Chong, Catherine D. ;
Schwedt, Todd J. .
HEADACHE, 2018, 58 (06) :827-835