Beyond biomarkers: Exploring the diverse potential of a novel phosphoprotein in lung cancer management

被引：0

作者：

Rostami, Amirabbas ^{[1
]}

Ranjbar, Ehsan ^{[2
]}

Amiri, Somayeh ^{[3
]}

Ezzatifar, Fatemeh ^{[4
]}

机构：

[1] Isfahan Univ Med Sci, Sch Med, Dept Internal Med, Esfahan, Iran

[2] Univ Tehran Med Sci, Uro Oncol Res Ctr, Dept Urol, Tehran, Iran

[3] Islamic Azad Univ, Fac Adv Sci & Technol, Dept Microbiol, Tehran Med Sci, Tehran, Iran

[4] Mazandaran Univ Med Sci, Dept Immunol, Sch Med, Farah Abad Rd, Sari, Iran

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2024年 / 28卷 / 18期

关键词：

autoantibody; diagnosis; lung cancer; nucleolin; prognosis; therapy; SURFACE-EXPRESSED NUCLEOLIN; CELL-SURFACE; IN-VIVO; MULTIVALENT PSEUDOPEPTIDES; OLIGONUCLEOTIDE AS1411; TARGETING NUCLEOLIN; HUMAN GLIOBLASTOMA; ENDOTHELIAL-CELLS; TUMOR-GROWTH; APTAMER;

D O I：

10.1111/jcmm.70077

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In addressing the challenges of lung cancer, attention has increasingly turned to molecular diagnostics and targeted therapies, with nucleolin (NCL) assuming a pivotal role, especially in non-small cell lung cancer. The aberrant activity and cellular distribution of NCL act as crucial biomarkers for early detection and treatment monitoring, showing a strong correlation with disease progression and patient prognosis. Elevated NCL levels signal advanced disease and poorer outcomes, underscoring its significance in evaluating disease severity and therapeutic response. Strategies targeting the molecular interactions of NCL have spurred innovative approaches to inhibit tumour growth, overcome drug resistance and improve treatment efficacy. These advancements are paving the way for personalized therapies tailored to the unique molecular profiles of patients' tumours. Consequently, NCL stands at the forefront of lung cancer management, symbolizing the move towards more precise and individualized oncology care, and marking substantial progress in therapeutic development.

引用

页数：11

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