Spherical nucleic acids for biomedical applications

被引：5

作者：

Xia, Chunxin ^{[1
]}

Cheng, Hemei ^{[1
]}

Hou, Xinwei ^{[1
]}

Zhang, Yu ^{[3
]}

Zhou, Xinchi ^{[1
]}

Yan, Qinglong ^{[1
,2
]}

Cao, Shuting ^{[1
,2
]}

机构：

[1] Xiangfu Lab, Jiaxing Key Lab Biosemiconductor, Jiashan 314102, Peoples R China

[2] Tsinghua Univ, Yangtze Delta Reg Inst, Nanotranslat Med Res Ctr, Jiaxing 314000, Zhejiang, Peoples R China

[3] Chinese Acad Sci, Shanghai Adv Res Inst, Interdisciplinary Res Ctr, Shanghai Synchrotron Radiat Facil, Shanghai 201210, Peoples R China

来源：

ADVANCED SENSOR AND ENERGY MATERIALS | 2024年 / 3卷 / 04期

基金：

中国国家自然科学基金; 上海市自然科学基金;

关键词：

Spherical nucleic acids; Conjugation mode; Biomedical detection; Imaging; Drug delivery; CELLULAR UPTAKE; GOLD NANOPARTICLES; GENE-REGULATION; DNA; DOXORUBICIN; PLATFORM;

D O I：

10.1016/j.asems.2024.100117

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Spherical nucleic acids (SNAs) are a 3D spherical nanostructure composed of highly oriented, dense layers of oligonucleotides conjugated to a hollow or solid core. This structure allows SNAs to show resistance to nuclease degradation, enter into nearly all cells without transfection agents and enable precise interactions with target molecules. Based on superior biological properties, SNAs can be tailored for diverse biological applications, rendering them a flexible and biosafe tool for biological applications as well as an enabling platform for therapy. In this review, we mainly discuss the structure and conjugation mode of SNAs and focus on recent advances in their applications, such as biomedical detection, imaging, and drug delivery. Finally, the remaining challenges and future directions of SNAs are also discussed and proposed.

引用

页数：13

共 114 条

[1] Spherical nucleic acids with tailored DNA conformation via bromide backfilling for the detection of kanamycin [J].

Bai, Long ;

Ye, Tai ;

Zhu, Dongdong ;

Sun, Donghao ;

Zhang, Shuyi ;

Lu, Yujie ;

Yuan, Min ;

Cao, Hui ;

Hao, Liling ;

Wu, Xiuxiu ;

Yin, Fengqin ;

Xu, Fei .

LUMINESCENCE, 2022, 37 (11) :1964-1971

[2] Liposomal Spherical Nucleic Acids [J].

Banga, Resham J. ;

Chernyak, Natalia ;

Narayan, Suguna P. ;

Nguyen, SonBinh T. ;

Mirkin, Chad A. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2014, 136 (28) :9866-9869

[3] Design Considerations for RNA Spherical Nucleic Acids (SNAs) [J].

Barnaby, Stacey N. ;

Perelman, Grant A. ;

Kohlstedt, Kevin L. ;

Chinen, Alyssa B. ;

Schatz, George C. ;

Mirkin, Chad A. .

BIOCONJUGATE CHEMISTRY, 2016, 27 (09) :2124-2131

[4] Precision spherical nucleic acids for delivery of anticancer drugs [J].

Bousmail, Danny ;

Amrein, Lilian ;

Fakhoury, Johans J. ;

Fakih, Hassan H. ;

Hsu, John C. C. ;

Panasci, Lawrence ;

Sleiman, Hanadi F. .

CHEMICAL SCIENCE, 2017, 8 (09) :6218-6229

[5] Impact of Liposomal Spherical Nucleic Acid Structure on Immunotherapeutic Function [J].

Callmann, Cassandra E. ;

Kusmierz, Caroline D. ;

Dittmar, Jasper W. ;

Broger, Leah ;

Mirkin, Chad A. .

ACS CENTRAL SCIENCE, 2021, 7 (05) :892-899

[6] Tumor cell lysate-loaded immunostimulatory spherical nucleic acids as therapeutics for triple-negative breast cancer [J].

Callmann, Cassandra E. ;

Cole, Lisa E. ;

Kusmierz, Caroline D. ;

Huang, Ziyin ;

Horiuchi, Dai ;

Mirkin, Chad A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (30) :17543-17550

[7] Doxorubicin: The Good, the Bad and the Ugly Effect [J].

Carvalho, Cristina ;

Santos, Renato X. ;

Cardoso, Susana ;

Correia, Sonia ;

Oliveira, Paulo J. ;

Santos, Maria S. ;

Moreira, Paula I. .

CURRENT MEDICINAL CHEMISTRY, 2009, 16 (25) :3267-3285

[8] Maximizing TLR9 Activation in Cancer Immunotherapy with Dual-Adjuvanted Spherical Nucleic Acids br [J].

Chen, Peiru ;

Wang, Dali ;

Wang, Yuyan ;

Zhang, Lei ;

Wang, Qiwei ;

Liu, Lanxia ;

Li, Jiahe ;

Sun, Xin ;

Ren, Mengqi ;

Wang, Ruoxuan ;

Fang, Yang ;

Zhao, Jean J. ;

Zhang, Ke .

NANO LETTERS, 2022, 22 (10) :4058-4066

[9] DNA-Grafted Hyaluronic Acid System with Enhanced Injectability and Biostability for Photo-Controlled Osteoarthritis Gene Therapy [J].

Chen, Zhijie ;

Zhang, Feng ;

Zhang, Hongbo ;

Cheng, Liang ;

Chen, Kaizhe ;

Shen, Jieliang ;

Qi, Jin ;

Deng, Lianfu ;

He, Chuan ;

Santos, Helder A. ;

Cui, Wenguo .

ADVANCED SCIENCE, 2021, 8 (09)

[10] The Impact of Protein Corona Formation on the Macrophage Cellular Uptake and Biodistribution of Spherical Nucleic Acids [J].

Chinen, Alyssa B. ;

Guan, Chenxia M. ;

Ko, Caroline H. ;

Mirkin, Chad A. .

SMALL, 2017, 13 (16)

← 1 2 3 4 5 6 7 8 9 10 →