Photobiomodulation improves functional recovery after mild traumatic brain injury

被引:0
|
作者
Stevens, Andrew R. [1 ,2 ,3 ]
Hadis, Mohammed [3 ,4 ]
Thareja, Abhinav [1 ]
Anderson, Freya G. [1 ]
Milward, Michael R. [3 ,4 ]
Di Pietro, Valentina [1 ,2 ,5 ]
Belli, Antonio [1 ,2 ,5 ]
Palin, William [3 ,4 ,5 ]
Davies, David J. [1 ,2 ,3 ,5 ]
Ahmed, Zubair [1 ,2 ,5 ]
机构
[1] Univ Birmingham, Sch Infect Inflammat & Immunol, Dept Inflammat & Ageing, Neurosci & Ophthalmol, Birmingham B15 2TT, England
[2] Univ Hosp Birmingham, NIHR Surg Reconstruct & Microbiol Res Ctr, Birmingham, England
[3] Univ Birmingham, Sch Dent, Phototherapy Res Grp, Birmingham, England
[4] Univ Birmingham, Sch Dent, Birmingham, England
[5] Univ Birmingham, Ctr Trauma Sci Res, Birmingham, England
基金
英国医学研究理事会;
关键词
functional recovery; medical devices; neuroprotection; photobiomodulation; traumatic brain injury; REMOTE PHOTOBIOMODULATION; INFRARED LIGHT; LASER THERAPY; BEAM-WALKING; RAT MODEL; ACTIVATION; CASPASE-3; DEFICITS; CARE;
D O I
10.1002/btm2.10727
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Mild traumatic brain injury (mTBI) is a common consequence of head injury but there are no recognized interventions to promote recovery of the brain. We previously showed that photobiomodulation (PBM) significantly reduced the number of apoptotic cells in adult rat hippocampal organotypic slice cultures. In this study, we first optimized PBM delivery parameters for use in mTBI, conducting cadaveric studies to calibrate 660 and 810 nm lasers for transcutaneous delivery of PBM to the cortical surface. We then used an in vivo weight drop mTBI model in adult rats and delivered daily optimized doses of 660, 810 nm, or combined 660/810 nm PBM. Functional recovery was assessed using novel object recognition (NOR) and beam balance tests, whilst histology and immunohistochemistry were used to assess the mTBI neuropathology. We found that PBM at 810, 660 nm, or 810/660 nm all significantly improved both NOR and beam balance performance, with 810 nm PBM having the greatest effects. Histology demonstrated no overt structural damage in the brain after mTBI, however, immunohistochemistry using brain sections showed significantly reduced activation of both CD11b+ microglia and glial fibrillary acidic protein (GFAP)+ astrocytes at 3 days post-injury. Significantly reduced cortical localization of the apoptosis marker, cleaved caspase-3, and modest reductions in extracellular matrix deposition after PBM treatment, limited to choroid plexus and periventricular areas were also observed. Our results demonstrate that 810 nm PBM optimally improved functional outcomes after mTBI, reduced markers associated with apoptosis and astrocyte/microglial activation, and thus may be useful as a potential regenerative therapy.
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页数:17
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