Antiviral mechanisms of dietary polyphenols: recent developments as antiviral agents and future prospects in combating Nipah virus

被引:1
|
作者
Prabhu, S. [1 ]
Kalaimathi, K. [2 ]
Thiruvengadam, M. [3 ,4 ]
Ayyanar, M. [5 ]
Shine, K. [6 ]
Amalraj, S. [1 ]
Ceasar, S. Antony [7 ]
Priya, S. Padma [8 ]
Prakash, N. [9 ]
机构
[1] Rajagiri Coll Social Sci, Dept Biosci, Div Phytochem & Drug Design, Cochin 683104, Kerala, India
[2] Govt Coll Engn, Dept Chem, Thanjavur 613402, Tamil Nadu, India
[3] Konkuk Univ, Coll Sanghuh Life Sci, Dept Crop Sci, Seoul 05029, South Korea
[4] Saveetha Univ, Saveetha Inst Med & Tech Sci SIMATS, Saveetha Med Coll, Ctr Global Hlth Res, Chennai 600077, India
[5] Bharathidasan Univ, AVVM Sri Pushpam Coll Autonomous Poondi, PG & Res Dept Bot, Thanjavur 613503, Tamil Nadu, India
[6] King Saud Univ, Coll Sci, Dept Bot & Microbiol, Riyadh 11451, Saudi Arabia
[7] Rajagiri Coll Social Sci, Dept Biosci, Div Plant Mol Biol & Biotechnol, Cochin 683104, Kerala, India
[8] RAK Med & Hlth Sci Univ, RAK Coll Dent Sci, Oral Biol & Oral Pathol, Ras Al Khaymah, U Arab Emirates
[9] Annai Vailankanni Arts & Sci Coll, Dept Chem, Thanjavur 613007, Tamil Nadu, India
关键词
Polyphenols; Biosynthesis; Antiviral effects; Antioxidant; Anti-Nipah virus; HEPATITIS-B-VIRUS; ROSMARINIC ACID; OXIDATIVE STRESS; TEA CATECHINS; GREEN TEA; CURCUMIN; ANTIOXIDANT; INHIBITION; INFECTION; EXTRACT;
D O I
10.1007/s11101-024-10017-1
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Polyphenols are ubiquitous secondary metabolites found in plants that have attracted considerable attention owing to their diverse applications in various industries, including food, cosmetics, and pharmaceuticals. Particularly, the curcumin, rosmarinic acid, and catechins are known for their therapeutic potential and offer a range of benefits, including antioxidant, neuroprotective, anti-inflammatory, anti-cancer and antimicrobial properties. Most importantly, they have shown promise for combating viral infections. The effectiveness of these pharmacological properties has been demonstrated through rigorous in silico, in vitro, and in vivo studies. There are evidence that dietary and pharmaceutical polyphenols exert protective effects against viral infections. Therefore, this review aims to investigate the mechanisms of action of curcumin, rosmarinic acid, and catechins against serious viral diseases in the human race. According to the research report of previous results, we believe that the proposed molecules have various roles in preventing infection and supporting the healing process in cases of viral invasion by blocking viral entry, inhibiting virus replication, protecting blood vessels, and preventing superinfection. On the other hand, these act effectively as antioxidants by activating Nrf-2 and inhibiting the overexpression of epithelial proteins. To determine the anti-Nipah virus potential, these molecules were tested against fusion protein, glycoprotein, membrane protein, nucleoprotein and phosphoprotein of Nipah virus (NiV). Eventually, they were discovered to have greater inhibitory activity by exhibiting binding affinities with specific protein residues of the Nipah virus. Based on the results of the review and in silico validation, the present review suggests that curcumin, rosmarinic acid, ( -)-epicatechin and ( +)-gallocatechin may act as an effective inhibitor for the complications caused by Nipah virus.
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页数:37
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