Oxytocin pathway gene variation and corticostriatal resting-state functional connectivity

被引：0
作者：
Xiao, Shanshan [1 ,2 ]
Fischer, Hakan [1 ,3 ,4 ]
Ebner, Natalie C. [5 ,6 ,7 ]
Rukh, Gull [2 ]
Dang, Junhua [8 ]
Westberg, Lars [9 ]
Schioth, Helgi B. [2 ]
机构：
[1] Stockholm Univ, Dept Psychol, Campus Albano House 4,Albanovagen 12, SE-11419 Stockholm, Sweden
[2] Uppsala Univ, BMC, Dept Surg Sci Funct Pharmacol & Neurosci, Husargatan 3, S-75124 Uppsala, Sweden
[3] Stockholm Univ Brain Imaging Ctr SUBIC, SE-10691 Stockholm, Sweden
[4] Stockholm Univ, Karolinska Inst, Aging Res Ctr, Tomtebodavagen18 A, SE-17177 Stockholm, Sweden
[5] Univ Florida, Dept Psychol, POB 112250, Gainesville, FL 32611 USA
[6] Univ Florida, Cognit Aging & Memory Program, Clin Translat Res Program CAM CTRP, 2004 Mowry Rd, Gainesville, FL 32611 USA
[7] Univ Florida, McKnight Brain Inst, 1149 Newell Dr, Gainesville, FL 32610 USA
[8] Xi An Jiao Tong Univ, Inst Social Psychol, Sch Humanities & Social Sci, 28 Xianning West Rd, Xian 710049, Shaanxi, Peoples R China
[9] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Pharmacol, Box 431, SE-40530 Gothenburg, Sweden
来源：
COMPREHENSIVE PSYCHONEUROENDOCRINOLOGY | 2024年 / 20卷
基金：
中国国家自然科学基金; 瑞典研究理事会;
关键词：
Oxytocin pathway gene; Corticostriatal connectivity; Resting-state functional connectivity; UK Biobank; AUTISM SPECTRUM DISORDER; ATTACHMENT BRAIN; RECEPTOR; BEHAVIOR; RELEASE; PEPTIDE; SYSTEM;
D O I：
10.1016/j.cpnec.2024.100255
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Genetic variations in single nucleotide polymorphisms (SNPs) within oxytocin pathway genes have been linked to social behavior and neurodevelopmental conditions. However, the neurobiological mechanisms underlying these associations remain elusive. In this study, we investigated the relationship between variations of 10 SNPs in oxytocin pathway genes and resting-state functional connectivity among 55 independent components using a large sample from the UK Biobank (N approximate to 30,000). Our findings revealed that individuals with the GG genotype at rs4813627 within the oxytocin structural gene (OXT) OXT ) exhibited weaker resting-state functional connectivity in the corticostriatal circuit compared to those with the GA/AA genotypes. Empirical evidence has linked the GG genotype at OXT rs4813627 with a behavioral tendency of insensitivity to others. These results inform the neural mechanisms by which oxytocin-related genetic factors can influence social behavior.
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页数：7
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