Synthesis of acetylenic and 1,2,3-triazolyl analogs of fusidic acid

被引：0
|
作者：
Salimova, E. V. [1 ]
Parfenova, L. V. [1 ]
机构：
[1] Russian Acad Sci, Inst Petrochem & Catalysis, Ufa Fed Res Ctr, 141 Prosp Oktyabrya, Ufa 450075, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2024年 / 73卷 / 08期
关键词：
fusidic acid; azide-alkyne cycloaddition reaction; Sonogashira coupling; Cadiot-Chodkiewicz coupling; cross-coupling of terminal alkynes; ENANTIOSELECTIVE ADDITION; STEREOSELECTIVE-SYNTHESIS; ORGANOZINC REAGENTS; CARBONYL-COMPOUNDS; DIETHYLZINC; BISPIDINE; CATALYSTS; LIGANDS; COMPLEX; AMINODIOLS;
D O I：
10.1007/s11172-024-4354-z
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In continuation of our studies on modification of fusidane triterpenoids, the alkynyl moieties were introduced into fusidic acid to synthesize new compounds promising as antimicrobial and antitumor agents. Transformations of the triple bond via the CuI-catalyzed reactions afforded new 1,2,3-triazoles as well as mono- and diacetylenic derivatives.
引用
收藏
页码：2309 / 2315
页数：7
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