Dysregulated Non-Coding RNA Expression in T Cells from Patients with Ankylosing Spondylitis Contributes to Its Immunopathogenesis

被引:0
作者
Yu, Hui-Chun [1 ]
Wang, Sz-Tsan [1 ]
Lu, Ming-Chi [1 ,2 ]
机构
[1] Dalin Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Div Allergy Immunol & Rheumatol, Chiayi, Taiwan
[2] Tzu Chi Univ, Sch Med, Hualien, Taiwan
关键词
ankylosing spondylitis; T cells; non-coding RNAs; immunopathogenesis; cytokines; micro RNAs; BLOOD MONONUCLEAR-CELLS; PERIPHERAL-BLOOD; DISEASE-ACTIVITY; ABERRANT EXPRESSION; INDUCED AUTOPHAGY; PATHOGENESIS; SPONDYLOARTHRITIS; CLASSIFICATION; ASSOCIATION; EPIGENETICS;
D O I
10.3390/biomedicines12081873
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ankylosing spondylitis (AS) is a chronic inflammatory disorder characterized by inflammatory back pain and bony fusion of vertebral joints. Genetic associations and environmental factors have been proposed to explain the immunopathogenesis of AS. In the past few years, there have been major advances in understanding T cell dysfunction in AS. Clinically, targeting interleukin-17A, a major cytokine secreted by T helper 17 cells, has been approved for treating patients with active AS. Non-coding RNAs (ncRNAs) are RNA transcripts that do not translate into proteins. The ncRNAs regulate both innate and adaptive immunity and participate in the pathogenesis of autoimmune diseases, including AS. The main purpose of this article is to review the up-to-date studies investigating the aberrant expression of ncRNAs in T cells from patients with AS and to summarize their roles in its pathogenesis. After searching PubMed for studies published between January 2013 and June 2024, nine studies investigating the expression of ncRNAs in AS T cells were included. We found that aberrantly expressed ncRNAs in AS T cells could cause abnormal cytokine release, cell signaling abnormalities, and dysregulated cell proliferation and death, which contribute to the immunopathogenesis of AS. We discussed some limitations of these studies and suggested several research fields for further investigation.
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