A Comprehensive Review on Phage Therapy and Phage-Based Drug Development

被引：30

作者：

Cui, Longzhu ^{[1
]}

Watanabe, Shinya ^{[1
]}

Miyanaga, Kazuhiko ^{[1
]}

Kiga, Kotaro ^{[1
,2
]}

Sasahara, Teppei ^{[1
]}

Aiba, Yoshifumi ^{[1
]}

Tan, Xin-Ee ^{[1
]}

Veeranarayanan, Srivani ^{[1
]}

Thitiananpakorn, Kanate ^{[1
]}

Nguyen, Huong Minh ^{[1
]}

Wannigama, Dhammika Leshan ^{[3
]}

机构：

[1] Jichi Med Univ, Sch Med, Dept Infect & Immun, Div Bacteriol, Shimotsuke, 3290498, Japan

[2] Natl Inst Infect Dis, Res Ctr Drug & Vaccine Dev, Tokyo 1628640, Japan

[3] Yamagata Prefectural Cent Hosp, Dept Infect Dis & Infect Control, Yamagata 9902292, Japan

来源：

ANTIBIOTICS-BASEL | 2024年 / 13卷 / 09期

关键词：

bacteriophage; phage therapy; antimicrobial resistance; intracellular pathogen; biofilm generating pathogen; phage vector; antibacterial phage capsid; phage-based vaccines; phage-based medicine; HOST-RANGE; MYCOBACTERIUM-TUBERCULOSIS; ENGINEERED BACTERIOPHAGES; BACTERIAL-RESISTANCE; MEDIATED DELIVERY; DNA VACCINE; M13; PHAGE; T2; COLI; DEPOLYMERASES;

D O I：

10.3390/antibiotics13090870

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Phage therapy, the use of bacteriophages (phages) to treat bacterial infections, is regaining momentum as a promising weapon against the rising threat of multidrug-resistant (MDR) bacteria. This comprehensive review explores the historical context, the modern resurgence of phage therapy, and phage-facilitated advancements in medical and technological fields. It details the mechanisms of action and applications of phages in treating MDR bacterial infections, particularly those associated with biofilms and intracellular pathogens. The review further highlights innovative uses of phages in vaccine development, cancer therapy, and as gene delivery vectors. Despite its targeted and efficient approach, phage therapy faces challenges related to phage stability, immune response, and regulatory approval. By examining these areas in detail, this review underscores the immense potential and remaining hurdles in integrating phage-based therapies into modern medical practices.

引用

页数：47

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