Antimalarial Drug Strategies to Target Plasmodium Gametocytes

被引：14
作者：
Munro, Bruce A. [1 ]
Mcmorran, Brendan J. [1 ]
机构：
[1] Australian Natl Univ, Coll Hlth & Med, John Curtin Sch Med Res, Div Immunol & Infect Dis, Canberra, ACT 2601, Australia
来源：
PARASITOLOGIA | 2022年 / 2卷 / 02期
基金：
英国医学研究理事会;
关键词：
Plasmodium; gametocyte; antimalarial drug; gametocidal drug targets; TRANSMISSION-BLOCKING ACTIVITY; HIGH-THROUGHPUT ASSAY; FALCIPARUM GAMETOCYTES; SEXUAL DEVELOPMENT; METHYLENE-BLUE; PROTEIN-KINASE; DIHYDROOROTATE DEHYDROGENASE; MALARIA PARASITES; P.-FALCIPARUM; ERYTHROCYTE DEFORMABILITY;
D O I：
10.3390/parasitologia2020011
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Onward transmission of Plasmodium falciparum from humans to mosquitoes is dependent upon a specialised transmission stage called the gametocyte. Despite its critical role in transmission, key questions regarding gametocyte biology remain to be answered, and there are no widely prescribed therapeutics to eliminate them. Advances in our understanding of the biology of the gametocyte in combination with growing information regarding the mechanism of action of anti-plasmodial therapies provide an emerging view as to which of the biological processes of the gametocyte present viable targets for drug intervention and explain the variable activity of existing therapies. A deeper understanding of the gametocyte and transmission stages of P. falciparum is a path to identifying and characterising novel drug targets. This review will examine how a selection of current and potential gametocytocidals mediate their effect.
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收藏
页码：101 / 124
页数：24
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