Impact of fluorosis on molecular predictors in pathogenesis of type 2 diabetes associated microvascular complications

被引:0
作者
Meenakshi, Sarasa [1 ]
Bahekar, Triveni [1 ]
Narapaka, Pavan Kumar [1 ]
Pal, Biplab [2 ]
Prakash, Ved [3 ]
Dhingra, Sameer [1 ]
Kumar, Nitesh [4 ]
Murti, Krishna [1 ]
机构
[1] Natl Inst Pharmaceut Educ & Res, Dept Pharm Practice, Vaishali 844102, Bihar, India
[2] Lovely Profess Univ, Dept Pharmacol, Phagwara 144402, Punjab, India
[3] Indira Gandhi Inst Med Sci IGIMS, Dept Endocrinol, Bailey Rd, Patna 800014, Bihar, India
[4] Natl Inst Pharmaceut Educ & Res, Dept Pharmacol & Toxicol, Vaishali 844102, Bihar, India
关键词
Nephropathy; Neuropathy; Retinopathy; Diabetes; Fluoride; Biomarkers; KIDNEY INJURY BIOMARKERS; PARAOXONASE; FLUORIDE; NEPHROTOXICITY; NEUROTOXICITY; EXPRESSION; CELLS; HOMOCYSTEINE; OSTEOPONTIN; DYSFUNCTION;
D O I
10.1016/j.jtemb.2024.127506
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Aim: This review presents specific insights on the molecular underpinnings of the connection between fluorosis, type 2 diabetes, and microvascular complications, along with the novel biomarkers that are available for early detection. Summary: Fluoride is an essential trace element for the mineralization of teeth and bones in humans. Exposure to higher concentrations of fluoride has harmful effects that significantly outweigh its advantageous ones. Dental fluorosis and skeletal fluorosis are the common side effects of exposure to fluoride, which affect millions of individuals globally. Alongside, it also causes non-skeletal fluorosis, which affects the population suffering from non-communicable diseases like diabetes by impacting the soft tissues and causing diabetic microvascular complications. Previous studies reported the prevalence range of these diabetic complications of neuropathy (3-65 %), nephropathy (1-63 %), and retinopathy (2-33 %). Fluoride contributes to the development of these complications by causing oxidative stress, cellular damage, degrading the functioning capability of mitochondria, and thickening the retinal vein basement. Conclusion: Early diagnosis is a prompt way of prevention, and for that, biomarkers have emerged as an innovative and useful technique. This allows healthcare practitioners and policymakers in endemic areas to comprehend the molecular complexities involved in the advancement of diabetic microvascular problems in the context of high fluoride exposure.
引用
收藏
页数:12
相关论文
共 133 条
[1]   Impacts of Fluoride Neurotoxicity and Mitochondrial Dysfunction on Cognition and Mental Health: A Literature Review [J].
Adkins, Emily A. ;
Brunst, Kelly J. .
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2021, 18 (24)
[2]  
Akinrinade Ibukun Dorcas, 2015, Pathophysiology, V22, P39, DOI 10.1016/j.pathophys.2014.12.001
[3]   Health-related quality of life and associated factors among patients with diabetes mellitus at the University of Gondar referral hospital [J].
Aschalew, Andualem Yalew ;
Yitayal, Mezgebu ;
Minyihun, Amare .
HEALTH AND QUALITY OF LIFE OUTCOMES, 2020, 18 (01)
[4]   Trefoil Factor 3 Predicts Incident Chronic Kidney Disease: A Case-Control Study Nested within the Atherosclerosis Risk in Communities (ARIC) Study [J].
Astor, Brad C. ;
Koettgen, Anna ;
Hwang, Shih-Jen ;
Bhavsar, Nrupen A. ;
Fox, Caroline S. ;
Coresh, Josef .
AMERICAN JOURNAL OF NEPHROLOGY, 2011, 34 (04) :291-297
[5]   Decreased Serum Paraoxonase 1 Activity and Increased Serum Homocysteine and Malondialdehyde Levels in Age-Related Macular Degeneration [J].
Ates, Orhan ;
Azizi, Sedat ;
Alp, H. Hakan ;
Kiziltunc, Ahmet ;
Beydemir, Sukru ;
Cinici, Emine ;
Kocer, Ibrahim ;
Baykal, Orhan .
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 217 (01) :17-22
[6]   Association of PAI-1 and Fibrinogen With Diabetic Retinopathy in the Veterans Affairs Diabetes Trial (VADT) [J].
Azad, Nasrin ;
Agrawal, Lily ;
Emanuele, Nicholas V. ;
Klein, Ronald ;
Bahn, Gideon D. ;
McCarren, Madeline ;
Reaven, Peter ;
Hayward, Rodney ;
Duckworth, William .
DIABETES CARE, 2014, 37 (02) :501-506
[7]  
Basha M, 2013, INDIAN J MED RES, V137, P370
[8]   Serum paraoxonase 1 activity and lipid peroxidation levels in patients with age-related macular degeneration [J].
Baskol, G ;
Karakucuk, S ;
Oner, AO ;
Baskol, M ;
Kocer, D ;
Mirza, E ;
Saraymen, R ;
Üstdal, M .
OPHTHALMOLOGICA, 2006, 220 (01) :12-16
[9]   The role of urinary N-acetyl-β-D-glucosaminidase in early detection of acute kidney injury among pediatric patients with neoplastic disorders in a retrospective study [J].
Biro, Erika ;
Szegedi, Istvan ;
Kiss, Csongor ;
Olah, Anna V. ;
Dockrell, Mark ;
Price, Robert G. ;
Szabo, Tamas .
BMC PEDIATRICS, 2022, 22 (01)
[10]   Diabetes-Related Microvascular and Macrovascular Diseases in the Physical Therapy Setting [J].
Cade, W. Todd .
PHYSICAL THERAPY, 2008, 88 (11) :1322-1335