Effect of DNA methylation on the osteogenic differentiation of mesenchymal stem cells: concise review

被引：3
作者：
Lai, Zhihao [1 ]
Shu, Qing [1 ]
Song, Yue [1 ,2 ]
Tang, Ao [1 ,2 ]
Tian, Jun [1 ]
机构：
[1] Wuhan Univ, Zhongnan Hosp, Dept Rehabil Med, Wuhan, Peoples R China
[2] Wuhan Sports Univ, Coll Sports Med, Wuhan, Peoples R China
来源：
FRONTIERS IN GENETICS | 2024年 / 15卷
基金：
中国国家自然科学基金;
关键词：
mesenchymal stem cells (MSCs); DNA methylation; DNA methyltransferases (DNMTs); Ten-eleven translocation family proteins (TETs); osteogenic differentiation; signaling pathway; MARROW STROMAL CELLS; BONE-MARROW; GENE-EXPRESSION; EPIGENETIC REGULATION; DE-NOVO; OSTEOBLASTIC DIFFERENTIATION; APLASTIC-ANEMIA; CPG METHYLATION; SELF-RENEWAL; TET ENZYMES;
D O I：
10.3389/fgene.2024.1429844
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Mesenchymal stem cells (MSCs) have promising potential for bone tissue engineering in bone healing and regeneration. They are regarded as such due to their capacity for self-renewal, multiple differentiation, and their ability to modulate the immune response. However, changes in the molecular pathways and transcription factors of MSCs in osteogenesis can lead to bone defects and metabolic bone diseases. DNA methylation is an epigenetic process that plays an important role in the osteogenic differentiation of MSCs by regulating gene expression. An increasing number of studies have demonstrated the significance of DNA methyltransferases (DNMTs), Ten-eleven translocation family proteins (TETs), and MSCs signaling pathways about osteogenic differentiation in MSCs. This review focuses on the progress of research in these areas.
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页数：19
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