RNA N6-methyladenosine modification in arthritis: New insights into pathogenesis

被引：1

作者：

Chen, Haowei ^{[1
]}

Xuan, Anran ^{[1
]}

Shi, Xiaorui ^{[1
]}

Fan, Tianxiang ^{[1
,2
]}

Xue, Song ^{[1
,3
]}

Ruan, Jianzhao ^{[1
]}

Wang, Xiaoshuai ^{[1
]}

Tang, Su'an ^{[1
]}

Qi, Weizhong ^{[1
]}

Sun, Haitao ^{[4
]}

Liu, Canzhao ^{[5
]}

He, Shuai ^{[6
]}

Ding, Changhai ^{[1
,7
,8
]}

Zhu, Zhaohua ^{[1
,9
,10
]}

机构：

[1] Southern Med Univ, Zhujiang Hosp, Clin Res Ctr, 253 Ind Ave, Guangzhou 510280, Peoples R China

[2] Hong Kong Polytech Univ, Dept Rehabil Sci, Hong Kong, Peoples R China

[3] Anhui Med Univ, Affiliated Hosp 1, Dept Rheumatol, Hefei, Peoples R China

[4] Southern Med Univ, Zhujiang Hosp, Dept Neurosurg, Guangzhou, Peoples R China

[5] Southern Med Univ, Zhujiang Hosp, Translat Med Res Ctr, Dept Cardiovasc Med, Guangzhou, Peoples R China

[6] Southern Med Univ, Zhujiang Hosp, Dept Pharm, Guangzhou, Peoples R China

[7] South China Univ Technol, Guangzhou Peoples Hosp 1, Sch Med, Dept Rheumatol, Guangzhou, Peoples R China

[8] Univ Tasmania, Menzies Inst Med Res, Hobart, Tas, Australia

[9] Univ Sydney, Kolling Inst, Royal North Shore Hosp, Dept Rheumatol, Sydney, Australia

[10] Univ Sydney, Kolling Inst, Sydney Musculoskeletal Hlth, Sydney, Australia

来源：

MODERN RHEUMATOLOGY | 2024年 / 35卷 / 02期

基金：

中国国家自然科学基金;

关键词：

RNA N6-methyladenosine; arthritis; pathogenesis; epigenetics; molecular mechanisms; BODY-MASS INDEX; MESSENGER-RNA; OSTEOARTHRITIS RISK; ALKBH5; TRANSLATION; DEMETHYLASE; MECHANISM; PROTEINS; FATE; GENE;

D O I：

10.1093/mr/roae080

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The commonest type of eukaryotic RNA modification, N6-methyladenosine (m6A), has drawn increased scrutiny in the context of pathological functioning as well as relevance in determination of RNA stability, splicing, transportation, localization, and translation efficiency. The m6A modification plays an important role in several types of arthritis, especially osteoarthritis and rheumatoid arthritis. Recent studies have reported that m6A modification regulates arthritis pathology in cells, such as chondrocytes and synoviocytes via immune responses and inflammatory responses through functional proteins classified as writers, erasers, and readers. The aim of this review was to highlight recent advances relevant to m6A modification in the context of arthritis pathogenesis and detail underlying molecular mechanisms, regulatory functions, clinical applications, and future perspectives of m6A in arthritis with the aim of providing a foundation for future research directions.

引用

页码：203 / 214

页数：12

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