Chemical constituents from the leaves of Scutellaria baicalensis Georgi and their chemotaxonomic significance

The phytochemical investigation of the Scutellaria baicalensis Georgi (S. baicalensis) leaves separation obtained two phenols (1, 2), one coumarin (3), thirteen flavones (4-16). Compounds 7-16 are valuable chemical classification markers in S. baicalensis leaves. Their structures were further determined by spectroscopic method in which compounds 1, 2, 5, and 6 have not yet been reported to be isolated from S. baicalensis, serving as chemical classification markers for S. baicalensis. Furthermore, compounds 1-3, 5, 6, 8 and 10 were successfully isolated from S. baicalensis leaves for the first time. The most important is that the significance of chemical taxonomy was discussed, which can provide theoretical principle on the separation of S. baicalensis leaves for subsequent research.