Skin Development and Disease: A Molecular Perspective

被引:2
作者
Dermitzakis, Iasonas [1 ]
Chatzi, Despoina [1 ]
Kyriakoudi, Stella Aikaterini [1 ]
Evangelidis, Nikolaos [1 ]
Vakirlis, Efstratios [2 ]
Meditskou, Soultana [1 ]
Theotokis, Paschalis [1 ]
Manthou, Maria Eleni [1 ]
机构
[1] Aristotle Univ Thessaloniki, Sch Med, Dept Histol Embryol, Thessaloniki 54124, Greece
[2] Aristotle Univ Thessaloniki, Sch Med, Dept Dermatol & Venereol 1, Thessaloniki 54643, Greece
关键词
skin; epidermis; appendages; hair follicle; sweat glands; development; embryogenesis; molecular cues; disease; cancer; BASAL-CELL CARCINOMA; EPIDERMAL STEM-CELLS; HYPOHIDROTIC ECTODERMAL DYSPLASIA; HAIR FOLLICLE MORPHOGENESIS; EPITHELIAL-MESENCHYMAL TRANSITION; EPIDERMOLYSIS-BULLOSA SIMPLEX; SWEAT GLAND DEVELOPMENT; BETA-CATENIN ACTIVITY; LANGERHANS CELLS; KINDLER SYNDROME;
D O I
10.3390/cimb46080487
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Skin, the largest organ in the human body, is a crucial protective barrier that plays essential roles in thermoregulation, sensation, and immune defence. This complex organ undergoes intricate processes of development. Skin development initiates during the embryonic stage, orchestrated by molecular cues that control epidermal specification, commitment, stratification, terminal differentiation, and appendage growth. Key signalling pathways are integral in coordinating the development of the epidermis, hair follicles, and sweat glands. The complex interplay among these pathways is vital for the appropriate formation and functionality of the skin. Disruptions in multiple molecular pathways can give rise to a spectrum of skin diseases, from congenital skin disorders to cancers. By delving into the molecular mechanisms implicated in developmental processes, as well as in the pathogenesis of diseases, this narrative review aims to present a comprehensive understanding of these aspects. Such knowledge paves the way for developing innovative targeted therapies and personalised treatment approaches for various skin conditions.
引用
收藏
页码:8239 / 8267
页数:29
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