Mechanisms underlying the development of type 1 diabetes in ART-treated people living with HIV: an enigmatic puzzle

被引：0

作者：

Zaongo, Silvere D. ^{[1
]}

Zongo, Abel W. ^{[2
]}

Chen, Yaokai ^{[1
]}

机构：

[1] Chongqing Publ Hlth Med Ctr, Dept Infect Dis, Chongqing, Peoples R China

[2] Zhejiang Univ Technol, Coll Food Sci & Technol, Hangzhou, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷

关键词：

HIV; antiretroviral therapy; ART; type; 1; diabetes; T1DM; mechanisms; CD4(+) T-CELLS; PLASMACYTOID DENDRITIC CELLS; PANCREATIC LYMPH-NODES; ANTIRETROVIRAL THERAPY; IMMUNE RECONSTITUTION; BETA-CELLS; B-CELLS; PERIPHERAL-BLOOD; INFECTION; ONSET;

D O I：

10.3389/fimmu.2024.1470308

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immunopathogenesis of HIV infection remains poorly understood. Despite the widespread use of effective modern antiretroviral therapy (ART), people living with HIV (PLWH) are known to develop several comorbidities, including type 1 diabetes (T1DM). However, the etiology and critical mechanisms accounting for the onset of T1DM in the preceding context remain unknown. This article proposes to address this topic in order to provide further understanding and future research directions.

引用

页数：14

共 167 条

[1]

Aikpitanyi-Iduitua Godwin Aigbedo, 2022, Human Antibodies, V30, P177, DOI 10.3233/HAB-220014

[2] Induction of Diabetes in the RIP-B7.1 Mouse Model Is Critically Dependent on TLR3 and MyD88 Pathways and Is Associated With Alterations in the Intestinal Microbiome [J].

Alkanani, Aimon K. ;

Hara, Naoko ;

Lien, Egil ;

Ir, Diana ;

Kotter, Cassandra V. ;

Robertson, Charles E. ;

Wagner, Brandie D. ;

Frank, Daniel N. ;

Zipris, Danny .

DIABETES, 2014, 63 (02) :619-631

[3] IL-1α, IL-1β, and IFN-γ mark β cells for Fas-dependent destruction by diabetogenic CD4+ T lymphocytes [J].

Amrani, A ;

Verdaguer, J ;

T'hiessen, S ;

Bou, S ;

Santamaria, P .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (04) :459-468

[4] Human islet T cells are highly reactive to preproinsulin in 1 diabetes [J].

Anderson, Amanda M. ;

Landry, Laurie G. ;

Alkanani, Aimon A. ;

Pyle, Laura ;

Powers, Alvin C. ;

Atkinson, Mark A. ;

Mathews, Clayton E. ;

Roep, Bart O. ;

Michels, Aaron W. ;

Nakayama, Maki .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 118 (41)

[5] Elevated frequencies of highly activated CD4+ T cells in HIV+ patients developing immune reconstitution inflammatory syndrome [J].

Antonelli, Lis R. V. ;

Mahnke, Yolanda ;

Hodge, Jessica N. ;

Porter, Brian O. ;

Barber, Daniel L. ;

DerSimonian, Rebecca ;

Greenwald, Jamieson H. ;

Roby, Gregg ;

Mican, JoAnn ;

Sher, Alan ;

Roederer, Mario ;

Sereti, Irini .

BLOOD, 2010, 116 (19) :3818-3827

[6] Monocytes as Regulators of Inflammation and HIV-Related Comorbidities during cART [J].

Anzinger, Joshua J. ;

Butterfield, Tiffany R. ;

Angelovich, Thomas A. ;

Crowe, Suzanne M. ;

Palmer, Clovis S. .

JOURNAL OF IMMUNOLOGY RESEARCH, 2014, 2014

[7] Islet expression of type I interferon response sensors is associated with immune infiltration and viral infection in type 1 diabetes [J].

Apaolaza, Paola S. ;

Balcacean, Diana ;

Zapardiel-Gonzalo, Jose ;

Nelson, Grace ;

Lenchik, Nataliya ;

Akhbari, Pouria ;

Gerling, Ivan ;

Richardson, Sarah J. ;

Rodriguez-Calvo, Teresa .

SCIENCE ADVANCES, 2021, 7 (09)

[8] Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated β-Cell Death [J].

Arif, Sefina ;

Moore, Fabrice ;

Marks, Katherine ;

Bouckenooghe, Thomas ;

Dayan, Colin M. ;

Planas, Raquel ;

Vives-Pi, Marta ;

Powrie, Jake ;

Tree, Timothy ;

Marchetti, Piero ;

Huang, Guo Cai ;

Gurzov, Esteban N. ;

Pujol-Borrell, Ricardo ;

Eizirik, Decio L. ;

Peakman, Mark .

DIABETES, 2011, 60 (08) :2112-2119

[9] Positive effects of combined antiretroviral therapy on CD4(+) T cell homeostasis and function in advanced HIV disease [J].

Autran, B ;

Carcelain, G ;

Li, TS ;

Blanc, C ;

Mathez, D ;

Tubiana, R ;

Katlama, C ;

Debre, P ;

Leibowitch, J .

SCIENCE, 1997, 277 (5322) :112-116

[10] Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes [J].

Babon, Jenny Aurielle B. ;

DeNicola, Megan E. ;

Blodgett, David M. ;

Crevecoeur, Inne ;

Buttrick, Thomas S. ;

Maehr, Rene ;

Bottino, Rita ;

Naji, Ali ;

Kaddis, John ;

Elyaman, Wassim ;

James, Eddie A. ;

Haliyur, Rachana ;

Brissova, Marcela ;

Overbergh, Lut ;

Mathieu, Chantal ;

Delong, Thomas ;

Haskins, Kathryn ;

Pugliese, Alberto ;

Campbell-Thompson, Martha ;

Mathews, Clayton ;

Atkinson, Mark A. ;

Powers, Alvin C. ;

Harlan, David M. ;

Kent, Sally C. .

NATURE MEDICINE, 2016, 22 (12) :1482-+

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