Ferroptosis-related gene signature and clinical prognostic factors as prognostic marker for colon adenocarcinoma

被引:0
作者
Zeng, Qunzhang [1 ]
Han, Lin [2 ]
Hong, Qiuxia [3 ]
Wang, Guan-Cong [1 ]
Xue, Xia-Juan [1 ]
Fang, Yicong [1 ]
Liu, Jing [4 ]
机构
[1] Fujian Med Univ, Dept Colorectal & Anal Surg, Zhangzhou Affiliated Hosp, 59 Shengli West Rd, Zhangzhou 363000, Fujian, Peoples R China
[2] Fujian Med Univ, Zhangzhou Affiliated Hosp, Dept Gastroenterol, Zhangzhou 363000, Fujian, Peoples R China
[3] Fujian Med Univ, Zhangzhou Affiliated Hosp, Med Dept, Zhangzhou 363000, Fujian, Peoples R China
[4] Smartquerier Gene Technol Shanghai Co Ltd, Huahong Innovat Pk,Shenjiang Rd,Pudong New Area, Shanghai 201203, Peoples R China
关键词
Ferroptosis; Colon adenocarcinoma; Ferroptosis score; Prognostic model; COLORECTAL-CANCER; SURVIVAL; STATISTICS; EXPRESSION; PREDICTS;
D O I
10.1016/j.heliyon.2024.e33794
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Aim: To build a ferroptosis-related prognostic model for patients with colon adenocarcinoma (COAD). Methods: COAD expression profiles from The Cancer Genome Atlas were used as the training set and GSE39582 from Gene Expression Omnibus as the validation set. Differentially expressed ferroptosis-related genes between patients with COAD and normal controls were screened, followed by tumor subtype exploration based on ferroptosis-related gene expression levels. A ferroptosis score (FS) model was constructed using least absolute shrinkage and selection operator penalized Cox analysis. Based on FS, patients were subgrouped into high- and low-risk subgroups and overall survival was predicted. The potential prognostic value of the FS model and the clinical characteristics were investigated using receiver operating characteristic curves. Results: Twenty-four differentially expressed ferroptosis-related genes were identified, four of which (CYBB, PRNP, ACSL4, and ACSL6) were included in the prognostic signature. Moreover, age, pathological T stage, and tumor recurrence were independent prognostic factors for COAD. The FS model combined with three independent prognostic factors showed the best prognostic value (The Cancer Genome Atlas: area under the curve = 0.897; GSE39582: area under the curve = 0.858). Conclusion: The novel prognostic model for patients with COAD constructed by pairing the FS model with three important independent prognostic factors showed promising clinical predictive value.
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页数:12
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