Rational design, synthesis and biological evaluation 1,2,3-triazole aryl attached (4,6-dimethoxy-1,3,5-triazin-2-yl)thiazole derivatives as anticancer agents

被引：1

作者：

Charugandla, Renuka ^{[1
,2
]}

Chidara, Sridhar ^{[2
]}

Dasari, Ashok ^{[1
]}

Nalla, Somaiah ^{[3
]}

Korupolu, Raghu Babu ^{[2
]}

Raziya, S. K. ^{[4
]}

Bonige, Kishore Babu ^{[2
]}

机构：

[1] Visa Chem Pvt Ltd, IDA Cherlapalli,Phase 3, Hyderabad 500092, Telangana, India

[2] Andhra Univ, AU Coll Engn A, Dept Engn Chem, Visakhapatnam 530003, Andhra Pradesh, India

[3] Acharya Nagarjuna Univ, Dept Chem, Guntur 522510, Andhra Pradesh, India

[4] Visakha Inst Engn & Technol A, Dept Chem BS &H, Visakhapatnam 530027, India

来源：

RESULTS IN CHEMISTRY | 2024年 / 11卷

关键词：

Gedatolisib; 1,3,5-Triazine; Carboxyamidotriazole; 1,2,3-Triazole; Anticancer activity; CLICK CHEMISTRY; INHIBITORY-ACTIVITY; SAR;

D O I：

10.1016/j.rechem.2024.101806

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new library of 1,2,3-triazole aryl-attached (4,6-dimethoxy-1,3,5-triazin-2-yl) thiazoles ( 11a-j ) has been designed and synthesized and its structures were characterized by 1 H NMR 13 C NMR and mass spectral data. Further, these derivatives ( 11a-j ) were evaluated for their anticancer activity against four human cancer cell lines, including PC3 (prostate cancer), A549 (lung cancer), MCF-7 (breast cancer) and A2780 (ovarian cancer) by employing the MTT method, and the obtained results were compared with etoposide. Among all the examined compounds, 11a, 11b, 11c, 11i and 11j displayed the most promising activity. Particularly, two compounds 11a and 11b possessed good activity.

引用

页数：5

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