Italian Registry on Rare Urological Tumors (Meet-URO-23): The First Analysis on Collecting Duct Carcinoma of the Kidney

被引:0
作者
Giudice, Giulia Claire [1 ,2 ]
Maruzzo, Marco [3 ]
Verzoni, Elena [4 ]
Procopio, Giuseppe [4 ]
Bimbatti, Davide [3 ]
Sepe, Pierangela [4 ]
Maines, Francesca [5 ]
Grillone, Francesco [6 ]
Cavo, Alessia [7 ]
Santoni, Matteo [8 ]
Cordua, Nadia [9 ]
Pecoraro, Giovanna [10 ]
Prati, Veronica [11 ]
Di Napoli, Marilena [12 ]
Ollari, Eli [2 ]
Caruso, Giuseppe [1 ]
Simoni, Nicola [13 ]
Campobasso, Davide [14 ]
Buti, Sebastiano [1 ,2 ]
机构
[1] Univ Hosp Parma, Med Oncol Unit, Via Antonio Gramsci 14, I-43126 Parma, Italy
[2] Univ Parma, Dept Med & Surg, Parma, Italy
[3] Ist Oncol Veneto IOV IRCCS, Dept Oncol, Oncol Unit 1, Padua, Italy
[4] Fdn IRCCS Ist Nazl Tumori, Dept Med Oncol, Milan, Italy
[5] Osped S Chiara Trento, Oncol Med, Trento, Italy
[6] Azienda Osped Univ Renato Dulbecco, Med Oncol Unit, Catanzaro, Italy
[7] Villa Scassi Hosp, Oncol Unit, Genoa, Italy
[8] Hosp Macerata, Unit Oncol, Macerata, Italy
[9] IRCCS Humanitas Res Hosp, Dept Oncol, Rozzano, Italy
[10] AOU Federico II, Med Oncol Dept, Naples, Italy
[11] Michele & Pietro Ferrero Hosp, ASL CN2, Verduno, Italy
[12] Ist Nazl Tumori IRCCS Fdn G Pascale, Dept Urol & Gynecol, Naples, Italy
[13] Univ Hosp Parma, Radiotherapy Unit, Parma, Italy
[14] Univ Hosp Parma, Urol Unit, Parma, Italy
关键词
Collecting duct carcinoma; Bellini duct carcinoma; Registry; Rare; Genitourinary tumors; RENAL-CELL CARCINOMA; PLATINUM SALT; COMBINATION; GEMCITABINE; NIVOLUMAB; SURVIVAL; BELLINI;
D O I
10.1016/j.clgc.2024.102186
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The Meet-URO 23/I-RARE is a retrospective-prospective study on rare genitourinary cancer. This analysis described the characteristics and outcomes of 37 patients with collecting duct carcinoma. Median overall survival (OS) was 22.1 months and median progression-free survival (PFS) for first-line treatment was 3.3 months. Female sex and good performance status seemed associated to longer OS ( p = .030) and PFS ( p < .01), respectively. Introduction: Rare genitourinary tumors are lacking of randomized and observational data. We aimed to describe the clinical characteristics and outcomes of patients with collecting duct carcinoma (CDC) through the Meet-URO 23/IRARE database. Materials and Methods: We performed a multicentric retrospective-prospective study within the MeetURO network, enrolling patients from March 2021 (retrospectively up from 2011) until March 2023. The primary objective was to describe the clinical characteristics of patients with CDC, the secondary objectives were to assess the oncological outcomes in terms of relapse-free survival (RFS), progression-free survival (PFS), overall survival (OS) and objective response rate (ORR) to treatment. Results: 37 patients with CDC were enrolled. Four patients underwent only surgery, 33 received first-line systemic therapy. Median OS was 22.1 months (95% CI, 8.9-31.9). Median RFS for patients with localized disease at onset (n = 30) was 3.7 months (95% CI, 1.9-12.8), median PFS for first-line treatment was 3.3 months (95% CI, 2.7-9.9), with an ORR of 27%. Female sex and good performance status (PS) were associated with longer PFS ( P = .072 and P < .01, respectively) and OS ( P = .030 and P = .141, respectively). Conclusions: Patients with CDC had dismal prognosis, with scarce benefit from the available treatments. Female sex and good PS seemed to be associated with better prognosis.
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页数:17
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