Metal-Free 1,8-Diazabicyclo(5.4.0)-undec-7-ene Mediated Synthesis of α-Acetal Amides through Reaction of Glyoxylic Acid Acetalde with Aryl Isothiocyanates

被引：1

作者：

Ding Rou ^{[1
]}

Shi Siyu ^{[1
]}

Ma Chao ^{[1
]}

Wei Wei ^{[1
,2
]}

Lu Yufen ^{[1
]}

机构：

[1] Qufu Normal Univ, Sch Chem & Chem Engn, Qufu 273165, Shandong, Peoples R China

[2] Chinese Acad Sci, Northwest Inst Plateau Biol, CAS Key Lab Tibetan Med Res, Xining 810008, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 44卷 / 07期

关键词：

metal-free; alpha-acetalamide; glyoxylic acid; aryl isothiocyanate; TRANSAMIDATION; AMIDATION; CHEMISTRY; OXIDATION; PROGRESS; PEPTIDE; REAGENT; AMINES; CARBON;

D O I：

10.6023/cjoc202403029

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Metal-free condensation reaction of glyoxylic acid acetalde with aryl isothiocyanates leading to alpha-acetal amides has been reported. The present protocol, which simply utilizes 1,8-diazabicyclo(5.4.0)-undec-7-ene (DBU) as base, provides a green and efficient approach to construct a series of alpha-acetal amides in the absence of metal catalysts and stoichiometric amounts of coupling reagents.

引用

页码：2216 / 2222

页数：7

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