Secondary hemophagocytic lymphohistiocytosis triggered by Staphylococcus aureus bacteremia: A case report and systemic review

被引：0

作者：

Chung, Shih-Hao ^{[1
]}

Liu, Yen-Yu ^{[2
,3
,5
,6
]}

Huang, Shih-Ya ^{[1
]}

Sung, Meng-Ta ^{[4
]}

Wu, Alice Ying-Jung ^{[7
,8
]}

机构：

[1] MacKay Mem Hosp, Dept Internal Med, Taipei, Taiwan

[2] MacKay Mem Hosp, Cardiovasc Ctr, Taipei, Taiwan

[3] MacKay Mem Hosp, Dept Crit Care Med, Taipei, Taiwan

[4] MacKay Mem Hosp, Dept Internal Med, Div Hematol & Oncol, Taipei, Taiwan

[5] MacKay Med Coll, Dept Med, New Taipei City, Taiwan

[6] MacKay Med Coll, Inst Biomed Sci, New Taipei City, Taiwan

[7] Mackay Mem Hosp, Dept Internal Med, Div Infect Dis, Taipei, Taiwan

[8] Mackay Med Coll, New Taipei City, Taiwan

来源：

IDCASES | 2024年 / 37卷

关键词：

Hemophagocytic syndrome; Staphylococcus aureus; Sepsis; Bacteremia;

D O I：

10.1016/j.idcr.2024.e02031

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Adult haemophagocytic lymphohistiocytosis (HLH) is an infrequent and life-threatening condition. The most common triggers of HLH are malignancy and virus, and bacterial infections are rarely implicated. We present a case of HLH secondary to Staphylococcus aureus infection and systemically searched the PubMed database for publications on HLH associated with Staphylococcus aureus infection and reviewed nine cases from seven studies. A marked third of patients had infective endocarditis, while the mortality rate was 44 %. HLH developed in our case despite elimination of MRSA from the bloodstream, leading to eventual demise of our patient, suggesting that prolonged hyperimmune response may persist even after the elimination of initial triggering factor. Our case highlights the necessity of high clinical suspicion and prompt diagnosis of HLH.

引用

页数：6

共 19 条

[1] Epidemiology, characteristics, and outcomes of adult haemophagocytic lymphohistiocytosis in the USA, 2006-19: a national, retrospective cohort study [J].