IgA vasculitis induced by carboplatin plus nab-paclitaxel plus pembrolizumab in a patient with advanced lung squamous cell carcinoma: a case report

被引：1

作者：

Terashima, Yuto ^{[1
]}

Matsumoto, Masaru ^{[1
]}

Ozaki, Saeko ^{[2
]}

Nakagawa, Michiko ^{[2
]}

Nakagome, Shun ^{[3
]}

Terasaki, Yasuhiro ^{[4
]}

Iida, Hiroki ^{[1
]}

Mitsugi, Ryotaro ^{[1
]}

Kuramochi, Eri ^{[1
]}

Okada, Naoko ^{[1
]}

Inoue, Tomoyasu ^{[1
]}

Matsuki, Satoru ^{[1
]}

Kitagawa, Shingo ^{[1
]}

Fukuizumi, Aya ^{[1
]}

Onda, Naomi ^{[1
]}

Takeuchi, Susumu ^{[1
]}

Miyanaga, Akihiko ^{[1
]}

Kasahara, Kazuo ^{[1
]}

Seike, Masahiro ^{[1
]}

机构：

[1] Nippon Med Sch, Dept Pulm Med & Oncol, Grad Sch Med, Tokyo, Japan

[2] Nippon Med Sch, Grad Sch Med, Dept Dermatol, Tokyo, Japan

[3] Nippon Med Sch, Grad Sch Med, Dept Gastroenterol, Tokyo, Japan

[4] Nippon Med Sch, Grad Sch Med, Dept Analyt Human Pathol, Tokyo, Japan

来源：

FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷

关键词：

IgA vasculitis; immune-related adverse event; immune checkpoint inhibitor; pembrolizumab; non-small-cell lung cancer;

D O I：

10.3389/fimmu.2024.1370972

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A 73-year-old man with lung squamous cell carcinoma was administered carboplatin + nab-paclitaxel + pembrolizumab for four cycles. Subsequently, he presented with multiple purpuras on his extremities, joint swelling on his fingers, abdominal pain, and diarrhea, accompanied by acute kidney injury (AKI), increased proteinuria, hematuria, and elevated C-reactive protein levels. Skin biopsy showed leukocytoclastic vasculitis as well as IgA and C3 deposition in the vessel walls. Based on these findings, the patient was diagnosed with IgA vasculitis as an immune-related adverse event (irAE) induced by carboplatin + nab-paclitaxel + pembrolizumab. After discontinuation of pembrolizumab and glucocorticoids, the symptoms immediately resolved. Regular monitoring of skin, blood tests, and urinalysis are necessary, and the possibility of irAE IgA vasculitis should be considered in cases of purpura and AKI during treatment with immune checkpoint inhibitors.

引用

页数：6

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