Gold Nanoparticles for Retinal Molecular Optical Imaging

被引：3

作者：

Park, Sumin ^{[1
]}

Nguyen, Van Phuc ^{[2
,3
]}

Wang, Xueding ^{[1
]}

Paulus, Yannis M. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48105 USA

[2] Univ Michigan, Dept Ophthalmol & Visual Sci, Ann Arbor, MI 48105 USA

[3] Johns Hopkins Univ, Dept Ophthalmol, Baltimore, MD 21287 USA

[4] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21287 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 17期

关键词：

molecular imaging; gold nanoparticles; retinal imaging; optical imaging; photoacoustic microscopy; optical coherence tomography; fluorescence imaging; COHERENCE TOMOGRAPHY; CONTRAST AGENTS; PHOTOACOUSTIC MICROSCOPY; IN-VIVO; NEOVASCULARIZATION; NANORODS; FUTURE;

D O I：

10.3390/ijms25179315

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The incorporation of gold nanoparticles (GNPs) into retinal imaging signifies a notable advancement in ophthalmology, offering improved accuracy in diagnosis and patient outcomes. This review explores the synthesis and unique properties of GNPs, highlighting their adjustable surface plasmon resonance, biocompatibility, and excellent optical absorption and scattering abilities. These features make GNPs advantageous contrast agents, enhancing the precision and quality of various imaging modalities, including photoacoustic imaging, optical coherence tomography, and fluorescence imaging. This paper analyzes the unique properties and corresponding mechanisms based on the morphological features of GNPs, highlighting the potential of GNPs in retinal disease diagnosis and management. Given the limitations currently encountered in clinical applications of GNPs, the approaches and strategies to overcome these limitations are also discussed. These findings suggest that the properties and efficacy of GNPs have innovative applications in retinal disease imaging.

引用

页数：39

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