Pharmacology of boldine: summary of the field and update on recent advances

被引：1

作者：

Saez, Juan C. ^{[1
]}

Burrell, Justin C. ^{[2
,3
]}

Cahill, Catherine M. ^{[4
]}

Cullen, D. Kacy ^{[2
,3
]}

Devi, Lakshmi A. ^{[5
,6
,7
]}

Gilbert, Ryan J. ^{[8
,9
]}

Graham, Zachary A. ^{[10
]}

Gurvich, Vadim J. ^{[11
,12
]}

Havton, Leif A. ^{[7
,13
,14
]}

Iyengar, Ravi ^{[15
,16
]}

Khanna, Rajesh ^{[17
]}

Palermo, Edmund F. ^{[8
,18
]}

Siddiq, Mustafa ^{[15
,16
]}

Toro, Carlos A. ^{[14
,19
,20
]}

Vasquez, Walter ^{[1
]}

Zhao, Wei ^{[14
,19
,20
]}

Cardozo, Christopher P. ^{[14
,19
,20
]}

机构：

[1] Univ Valparaiso, Inst Neurociencias, Ctr Interdisciplinario Neurociencia Valparaiso, Valparaiso, Chile

[2] CMC VA Med Ctr, Ctr Neurotrauma Neurodegenerat & Restorat, Philadelphia, PA USA

[3] Univ Penn, Ctr Brain Injury & Repair, Perelman Sch Med, Dept Neurosurg, Philadelphia, PA USA

[4] Univ Calif Los Angeles, Psychiat & Biobehav Sci, Los Angeles, CA USA

[5] Icahn Sch Med Mt Sinai, Dept Pharmacol & Syst Therapeut, New York, NY USA

[6] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY USA

[7] Icahn Sch Med Mt Sinai, Nash Family Dept Neurosci, New York, NY USA

[8] Rensselaer Polytech Inst, Biomed Engn, Troy, NY USA

[9] Albany Stratton VA Med Ctr, New York, NY USA

[10] Florida Inst Human & Machine Cognit, Healthspan Resilience & Performance, Gainesville, FL USA

[11] Univ Minnesota, Inst Therapeut Discovery & Dev, Coll Pharm, Minneapolis, MN USA

[12] Univ Minnesota, Coll Pharm, Dept Med Chem, Minneapolis, MN USA

[13] Icahn Sch Med Mt Sinai, Dept Neurol, New York, NY USA

[14] James J Peters VA Med Ctr, Spinal Cord Damage Res Ctr, New York, NY 10468 USA

[15] Icahn Sch Med Mt Sinai, Dept Pharmacol Sci, New York, NY USA

[16] Icahn Sch Med Mt Sinai, Inst Syst Biomed, New York, NY USA

[17] Univ Florida, Dept Pharmacol & Therapeut, Gainesville, FL USA

[18] Rensselaer Polytech Inst, Mat Sci & Engn, New York, NY USA

[19] Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA

[20] Icahn Sch Med Mt Sinai, Dept Rehabil & Human Performance, New York, NY 10029 USA

来源：

FRONTIERS IN PHARMACOLOGY | 2024年 / 15卷

关键词：

boldine; hemichannels; pharmacology; connexin (Cx); phramacokinetics; MICROSOMAL LIPID-PEROXIDATION; IN-VITRO; CONNEXIN-43; HEMICHANNELS; ENDOTHELIAL FUNCTION; ALKALOID BOLDINE; ANTIOXIDANT; INHIBITION; STRESS; ASTROCYTES; EXPRESSION;

D O I：

10.3389/fphar.2024.1427147

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Over the past decade, boldine, a naturally occurring alkaloid found in several plant species including the Chilean Boldo tree, has garnered attention for its efficacy in rodent models of human disease. Some of the properties that have been attributed to boldine include antioxidant activities, neuroprotective and analgesic actions, hepatoprotective effects, anti-inflammatory actions, cardioprotective effects and anticancer potential. Compelling data now indicates that boldine blocks connexin (Cx) hemichannels (HCs) and that many if not all of its effects in rodent models of injury and disease are due to CxHC blockade. Here we provide an overview of boldine's pharmacological properties, including its efficacy in rodent models of common human injuries and diseases, and of its absorption, distribution, pharmacokinetics, and metabolism.

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页数：13

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