Kaempferol inhibited invasion and metastasis of gastric cancer cells by targeting AKT/GSK3β pathway based on network pharmacology and molecular docking

被引：0
|
作者：
Gao, Xia-Qing [1 ,5 ]
Li, Hai-Long [1 ,2 ]
Wang, Meng [3 ,4 ]
Yang, Chun-Ting [1 ,6 ]
Su, Rong [1 ]
Shao, Li-Hua [1 ]
机构：
[1] Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou 730000, Peoples R China
[2] Gansu Univ Chinese Med, Affiliated Hosp, Dept Geriatr, Lanzhou 730000, Peoples R China
[3] Mudanjiang Med Univ, Affiliated Hongqi Hosp, Dept Geriatr, Mudanjiang 157011, Peoples R China
[4] Res Ctr Tradit Chinese Med, Lanzhou 730000, Gansu, Peoples R China
[5] Gansu Univ Chinese Med, Key Lab Gansu Prov Prescript Min, Innovat Translat Lab, Lanzhou 730000, Peoples R China
[6] Gansu Univ Chinese Med, Gansu Prov Tradit Chinese Med New Prod Creat Engn, Lanzhou 730000, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2025年 / 27卷 / 03期
关键词：
Kaempferol; gastric cancer; AKT/GSK3 beta signaling pathway; invasion and metastasis; network pharmacology; TO-MESENCHYMAL TRANSITION; LUNG-CANCER; MIGRATION; APOPTOSIS; GROWTH; PROLIFERATION; PROGRESSION; ENHANCE; MICE; EMT;
D O I：
10.1080/10286020.2024.2387756
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
This study aims to explore the mechanisms of the inhibitory effect of kaempferol on the invasion and metastasis of gastric cancer (GC) cells through network pharmacology prediction and experimental verification. It identifies core targets via PPI network analysis and finds that kaempferol binds to these targets well. In vitro experiments showed that kaempferol could inhibit the proliferation, colony formation, migration and invasion of GC cells. Western blotting indicated kaempferol may reduce AKT and GSK3 beta phosphorylation, leading to lower expression of invasion-related genes SRC, MMP9, CXCR4, KDR, and MMP2. Overall, kaempferol may prevent migration and invasion of GC cells via the AKT/GSK3 beta signaling pathway.
引用
收藏
页码：421 / 441
页数：21
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