Distrust in the Health Care System and Adherence to Direct-Acting Antiviral Therapy among People with Hepatitis C Virus Who Inject Drugs

被引：1

作者：

Padi, Akhila ^{[1
]}

Pericot-Valverde, Irene ^{[2
,3
]}

Heo, Moonseong ^{[4
]}

Dotherow, James Edward ^{[4
]}

Niu, Jiajing ^{[5
]}

Martin, Madhuri ^{[6
]}

Norton, Brianna L. ^{[7
]}

Akiyama, Matthew J. ^{[7
]}

Arnsten, Julia H. ^{[7
]}

Litwin, Alain H. ^{[2
,3
,6
,8
]}

机构：

[1] Washington Univ, Dept Med, Sch Med, St Louis, MO 63110 USA

[2] Clemson Univ, Dept Psychol, Clemson, SC 29634 USA

[3] Addict Med Ctr, Dept Med, Prisma Hlth, Greenville, SC 29605 USA

[4] Clemson Univ, Dept Publ Hlth Sci, Clemson, SC 29634 USA

[5] Clemson Univ, Sch Math & Stat Sci, Clemson, SC 29634 USA

[6] Univ South Carolina, Dept Med, Sch Med, Greenville, SC 29615 USA

[7] Albert Einstein Coll Med, Montefiore Med Ctr, Bronx, NY 10461 USA

[8] Prisma Hlth, Dept Med, 605 Grove Rd,Suite 205, Greenville, SC 29605 USA

来源：

VIRUSES-BASEL | 2024年 / 16卷 / 08期

关键词：

hepatitis C; PWIDs; DAAs; OAT; ANTIRETROVIRAL THERAPY; MEDICAL MISTRUST; TRUST; HIV; DISPARITIES; RACE; DISCRIMINATION; PHYSICIANS; PROVIDERS; SERVICES;

D O I：

10.3390/v16081304

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

This study is a secondary analysis of a randomized clinical trial (October 2013-April 2017) involving 150 People Who Inject Drugs (PWIDs) with hepatitis C virus (HCV) seen in opioid agonist treatment programs in the Bronx, New York, and investigates the impact of distrust in the healthcare system on adherence to Direct-Acting Antivirals (DAAs) HCV treatment therapy among PWIDs. The distrust was scaled on a 9-item instrument and the adherence to DAA medications was measured using electronic blister packs. This study demonstrated a significant inverse relationship between levels of distrust and medication adherence: 71.8 +/- 2.2% (se) vs. 77.9 +/- 1.8%, p = 0.024 between participants with higher and lower distrust levels. Despite the absence of significant association of distrust with sociodemographic or substance use characteristics, these findings suggest that building trust within the healthcare system is paramount for improving adherence to DAAs among PWIDs. The results call for a healthcare approach that emphasizes trust-building through patient-centered care, sensitivity training, peer support, and health system reform to effectively address the treatment needs of this marginalized population.

引用

页数：12

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