Dehydrogenative N-N Coupling and Facile Synthesis of Cobalt Complexes Supported by Tetrazene Based Ligand: Synthesis of Quinolines and Quinazolinones via Activation of Alcohols

Herein we first report the unprecedented synthesis of tetrazene-based cobalt complexes using unusual coupling of amines via dehydrogenation. These cobalt complexes were employed for dehydrogenative coupling reactions to synthesize N-heterocycles (quinoline, and quinazolinone). Based on control experiments and IR identification of intermediates, we proposed a plausible reaction mechanism. Synthesis protocols were utilized for preparative scale synthesis and biologically active molecule (+/-)-galipinine synthesis. This work reports the unprecedented synthesis of tetrazene-based cobalt complexes using unusual coupling of amines via dehydrogenation. These cobalt complexes were employed for dehydrogenative coupling reactions to synthesize N-heterocycles (quinoline, and quinazolinone). The mechanistic investigation involved conducting control experiments and identifying intermediates through IR spectroscopy. image