Tryptophan Metabolism Disorder-Triggered Diseases, Mechanisms, and Therapeutic Strategies: A Scientometric Review

被引:1
|
作者
Chen, Xue [1 ,2 ]
Xu, Dong [1 ,2 ]
Yu, Jie [1 ,2 ]
Song, Xu-Jiao [1 ,2 ]
Li, Xue [1 ,2 ]
Cui, Yuan-Lu [1 ,2 ]
机构
[1] Tianjin Univ Tradit Chinese Med, Haihe Lab Modern Chinese Med, Tianjin 301617, Peoples R China
[2] Tianjin Univ Tradit Chinese Med, Res Ctr Tradit Chinese Med, State Key Lab Component Based Chinese Med, Tianjin 301617, Peoples R China
关键词
tryptophan metabolism; scientometric analysis; gut microbiota; COVID-19; depression; ARYL-HYDROCARBON RECEPTOR; DEPRESSIVE-LIKE BEHAVIOR; INDOLEAMINE 2,3-DIOXYGENASE; GUT MICROBIOTA; KYNURENINE PATHWAY; IMMUNE CHECKPOINT; UP-REGULATION; MOUSE MODEL; ACID; INHIBITOR;
D O I
10.3390/nu16193380
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: Tryptophan is widely present in foods such as peanuts, milk, and bananas, playing a crucial role in maintaining metabolic homeostasis in health and disease. Tryptophan metabolism is involved in the development and progression of immune, nervous, and digestive system diseases. Although some excellent reviews on tryptophan metabolism exist, there has been no systematic scientometric study as of yet. Methods: This review provides and summarizes research hotspots and potential future directions by analyzing annual publications, topics, keywords, and highly cited papers sourced from Web of Science spanning 1964 to 2022. Results: This review provides a scientometric overview of tryptophan metabolism disorder-triggered diseases, mechanisms, and therapeutic strategies. Conclusions: The gut microbiota regulates gut permeability, inflammation, and host immunity by directly converting tryptophan to indole and its derivatives. Gut microbial metabolites regulate tryptophan metabolism by activating specific receptors or enzymes. Additionally, the kynurenine (KYN) pathway, activated by indoleamine-2, 3-dioxygenase (IDO) and tryptophan 2, 3-dioxygenase, affects the migration and invasion of glioma cells and the development of COVID-19 and depression. The research and development of IDO inhibitors help to improve the effectiveness of immunotherapy. Tryptophan metabolites as potential markers are used for disease therapy, guiding clinical decision-making. Tryptophan metabolites serve as targets to provide a new promising strategy for neuroprotective/neurotoxic imbalance affecting brain structure and function. In summary, this review provides valuable guidance for the basic research and clinical application of tryptophan metabolism.
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页数:26
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