Multimodality Imaging of Acute Myocarditis in Cytokine Release Syndrome (CRS) Following CAR-T Therapy

被引：0

作者：

Maheswaran, Janane ^{[1
]}

Rafice, Moezedin Javad ^{[2
]}

Cordes, Sydney ^{[3
]}

Lefebvre, Benedicte ^{[4
]}

Chetrit, Michael ^{[1
,2
]}

机构：

[1] McGill Univ, Div Cardiol, Montreal, PQ, Canada

[2] McGill Univ, Div Diag Radiol, Montreal, PQ, Canada

[3] Wilfrid Laurier Univ, Waterloo, ON, Canada

[4] Univ Penn, Div Cardiol, Philadelphia, PA USA

来源：

CJC OPEN | 2024年 / 6卷 / 08期

关键词：

D O I：

10.1016/j.cjco.2024.04.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chimeric antigen receptor (CAR T)-cell therapy is a novel immunotherapy with promising results for patients with advanced malignancies.(1 )Cytokine release syndrome is an adverse effect of this therapy, associated with multiorgan, including cardiovascular, complications.(1) We describe a case of CAR T-cell-associated cardiotoxicity and the associated multimodality imaging findings.

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收藏

页码：973 / 977

页数：5

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共 7 条

[1] Chimeric Antigen Receptor T-Cell Therapy-Associated Cardiomyopathy in Patients With Refractory or Relapsed Non-Hodgkin Lymphoma [J].

Ganatra, Sarju ;

Redd, Robert ;

Hayek, Salim S. ;

Parikh, Rohan ;

Azam, Tariq ;

Yanik, Gregory A. ;

Spendley, Lauren ;

Nikiforow, Sarah ;

Jacobson, Caron ;

Nohria, Anju .

CIRCULATION, 2020, 142 (17) :1687-1690

[2] CAR T Cell Therapy-Related Cardiovascular Outcomes and Management Systemic Disease or Direct Cardiotoxicity? [J].

Ghosh, Arjun K. ;

Chen, Daniel H. ;

Guha, Avirup ;

Mackenzie, Strachan ;

Walker, J. Malcolm ;

Roddie, Claire .

JACC: CARDIOONCOLOGY, 2020, 2 (01) :98-109

[3] Fulminant fatal cardiotoxicity following cyclophosphamide therapy [J].

Katayama, Minako ;

Imai, Yukihiro ;

Hashimoto, Hisako ;

Kurata, Masayuki ;

Nagai, Kenichi ;

Tamita, Koichi ;

Morioka, Shigefumi ;

Furukawa, Yutaka .

JOURNAL OF CARDIOLOGY, 2009, 54 (02) :330-334

[4] ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells [J].

Lee, Daniel W. ;

Santomasso, Bianca D. ;

Locke, Frederick L. ;

Ghobadi, Armin ;

Turtle, Cameron J. ;

Brudno, Jennifer N. ;

Maus, Marcela, V ;

Park, Jae H. ;

Mead, Elena ;

Pavletic, Steven ;

Go, William Y. ;

Eldjerou, Lamis ;

Gardner, Rebecca A. ;

Frey, Noelle ;

Curran, Kevin J. ;

Peggs, Karl ;

Pasquini, Marcelo ;

DiPersio, John F. ;

van den Brink, Marcel R. M. ;

Komanduri, Krishna, V ;

Grupp, Stephan A. ;

Neelapu, Sattva S. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2019, 25 (04) :625-638

[5] Strain Imaging in Cardio-Oncology [J].

Liu, Jennifer E. ;

Barac, Ana ;

Thavendiranathan, Paaladinesh ;

Scherrer-Crosbie, Marielle .

JACC: CARDIOONCOLOGY, 2020, 2 (05) :677-689

[6] The Septic Heart Current Understanding of Molecular Mechanisms and Clinical Implications [J].

Martin, Lukas ;

Derwall, Matthias ;

Al Zoubi, Sura ;

Zechendorf, Elisabeth ;

Reuter, Daniel A. ;

Thiemermann, Chris ;

Schuerholz, Tobias .

CHEST, 2019, 155 (02) :427-437

[7] Characterization of critically ill patients with septic shock and sepsis-associated cardiomyopathy using cardiovascular MRI [J].

Muehlberg, Fabian ;

Blaszczyk, Edyta ;

Will, Kerstin ;

Wilczek, Stefan ;

Brederlau, Joerg ;

Schulz-Menger, Jeanette .

ESC HEART FAILURE, 2022, 9 (04) :2147-2156