Hypofractionated radiation therapy alone for human papillomavirus-related oropharyngeal cancer

被引：0
作者：
Chen, Allen M. [1 ]
Harris, Jeremy P. [1 ]
Tjoa, Tjoson [2 ]
Haidar, Yarah [2 ]
Armstrong, William B. [2 ]
机构：
[1] Univ Calif Irvine, Chao Family Comprehens Canc Ctr, Dept Radiat Oncol, 101 City Dr,Bldg 23, Orange, CA 92868 USA
[2] Univ Calif Irvine, Chao Family Comprehens Canc Ctr, Dept Otolaryngol, Orange, CA USA
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2025年 / 47卷 / 01期
关键词：
cancer; HPV; hypofractionation; oropharyngeal; radiation; SQUAMOUS-CELL CARCINOMA; NECK-CANCER; POSITIVE HEAD; SINGLE-ARM; RADIOTHERAPY; CHEMOTHERAPY; SURVIVAL;
D O I：
10.1002/hed.27908
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
PurposeTo report a single-institutional experience with hypofractionated radiation therapy alone for human papillomavirus (HPV)-positive oropharyngeal cancer.Methods and materialsA total of 101 consecutive patients were treated by radiation therapy alone using a regimen of 66 Gy in 30 fractions (60 patients) or 70 Gy in 33 fractions (41 patients) for newly diagnosed p16-positive squamous cell carcinoma of the oropharynx. Sixty-seven patients (67%) were never smokers.ResultsThe 3-year actuarial rates of overall survival, local-regional control, and progression-free survival were 94%, 93%, and 89%, respectively. Among never-smokers, the 3-year rates of overall survival and local-regional control were 98% and 100%, respectively. The grade 3+ acute toxicity rate was 21%, with the most commonly observed side effects related to mucositis.ConclusionHypofractionated radiation alone resulted in excellent outcomes for patients with HPV-positive oropharyngeal cancer. A prospective clinical trial investigating this modality in the setting of de-escalation is currently underway.
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页码：235 / 241
页数：7
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